The SOX (SRY-box containing gene) gene family encodes a group of transcription factors defined by the conserved high motility group (HMG) DNA-binding domain.
SOX6 is a transcriptional factor that is specifically expressed in the developing central nervous system and in the early stages of chondrogenesis in mouse embryos. Results indicate that the developmentally regulated transcription factor SOX6 is aberrantly expressed in glioma.
Image: Labeling for SOX6 in the notochord of 12 d.p.c. mouse embryos. Detection was done using anti-rabbit-Cy3 conjugated secondary antibodies (red fluorescence). Cell nuceli were counterstained with DAPI (blue fluorescence). Mounted with i-BRITE Plus