Product Details
Catalog Number: RA19077
Applications: WB, IHC
Type: Rabbit IgG
Immunogen: Disaggregated paired helical filaments were used as an immunogen. Insoluble NFT which were extracted in boiling sodium dodecyl sulfate, purified by sucrose gradient centrifugation and disaggregated by sonication were used as an immunogen for the preparation of this antibody.
Format A: Whole serum
Format B: liquid
Species Reactivity: Human
Downloads: Datasheet (pdf)
Product Sizes
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100 ul$295.00Add to Cart

The neurofibrillary tangles (NFT) are neuronal inclusions that are the hallmark lesions of Alzheimer’s disease (AD). These tangles are made up of paired helical filaments (PHF). The PHF are highly insoluble structures and are known to be composed of a highly phosphorylated form of the microtubule-associated protein tau and may contain associated lipid.

Image: Western blot analysis of Alzheimer disease brain and a purified preparation of disaggregated paired helical filaments (PHF) using Neurofibrillary Tangles Antibody. The majority of insoluble PHF are excluded from the stacking gel (O1) and with the remaining material being excluded from the origin of the seperating gel (O2).