VR1 C-Terminus (TRPV1) - mouse specific

TRPV1 antagonists have shown efficacy in reducing nociception from inflammatory and neuropathic pain models in rats.[11] This provides evidence that TRPV1 is the capsaicin's sole receptor. In humans, drugs acting at TRPV1 receptors could potentially be used to treat neuropathic pain associated with multiple sclerosis, chemotherapy, or amputation, as well as pain associated with the inflammatory response of damaged tissue, such as in osteoarthritis.

Image of VR1 immunoreactivity in mouse dorsal root ganglion. Animals were perfusion fixed with 2% paraformaldehyde. Image courtesy of Dr. Zunyi Wang, University of Wisconsin, Madison.

TRPV1-mouse specific: Customer Data and Publications 

Images: A Confocal image stack through GCL and NFL of peripheral retina shows TRPV1 in retinal ganglion cell (RGC) bodies (bracket) and in small bundles of RGC axons (arrows). G  top: Western blot against TRPV1 in brain and whole retina from adult rat shows band at expected molecular weight (arrowheads; 100–113 kDa). Retina demonstrates an additional band with a slightly lower molecular weight that probably corresponds to a different glycosylation state for this antibody. bottom: Control Western blot with preabsorption of TRPV1 antibody using the blocking peptide prevents detection of both bands. ONL, outer nuclear layer; OPL, outer plexiform layer; INL, inner nuclear layer; IPL, inner plexiform layer; GCL, ganglion cell layer; NFL, nerve fiber layer. doi:10.1167/iovs.08-2321 on October 24, 2008 (Investigative Ophthalmology and Visual Science. 2009;50:717-728).

Image: TRPV1 staining of mouse inferior olive using Cy3-conjugated donkey anti-rabbit secondary antibodies (red color) and DAPI (blue) as a nuclear counterstain.