|Catalog Number||Size||Price (USD)||Shopping Cart|
|GT41018||100 ug||$299.00||Buy Now | Add to Cart|
|P41018||100 ug Blocking Peptide||$145.00||Buy Now | Add to Cart|
Cell adhesion molecule 4, CADM4, Immunoglobulin superfamily member 4C, IGSF4C or NECL-4. An immunohistochemical study reveals that CADM4 is expressed at the cell-cell attachment sites in the renal tubules, the transitional epithelia of the bladder, and the glandular epithelia of the prostate.
Image: CADM4 (Dilution:2. 5μg/ml) staining of paraffin embedded Human Thymus. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
CADM4 is also in the telencephalic wall, whereas it becomes rather confined to the subplate, the cortical plate and the subventricular zone during development. It gradually decreases after birth and disappears in adulthood. It remains at low levels throughout embryonic stage. These spatiotemporal patterns of the expression suggest that CADM4 plays crucial roles in the development of both telencephalon and cerebellum. CADM is ectopically expressed in adult T-cell leukemia (ATL) cells, providing not only a diagnostic marker for ATL, but also a possible therapeutic target against its invasion.
Image: Staining of Human Brain (Cerebellum) lysate (35µg protein in RIPA buffer) with CADM4. Primary incubation was 1 hour. Detected by chemiluminescence.