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Type: Goat IgG
 
Applications: E; IHC; WB
E=ELISA; FACS; FC=Flow Cytometry; FPLC=Fast Protein Liquid Chromatography; GF=Gravity Flow; HPLC=High Performance Liquid Chromatography; ICC=Immunocytochemistry; IF=Immunofluorescence; IHC=Immunohistochemistry; IP=Immunoprecipitation; NAC=Non-adherent Cell Assays; NB=Neutralization of Bioactivity; SE=Sandwich ELISA; TPE=Targeted Protein Expression; WB=Western blotting; ; AC=Adherent Cell Assays; FM=Fluorescent Micsroscopy; ; ; BSC-CM5= Biacore Sensor Chip CM5; BSM=Biosactive Small Molecule or Peptide; CDM=Cell Differentiation Media; ; ; ; ; ; Health and Fitness; ; ; DNA Extraction/Purification; ; In vivo Like Assays
Species Reactivity: H; M; R
B=Bovine; Ca=Cat; Ch=Chicken; D=Dog; EQ=Equine; GP=Guinea Pig; H=Human; M=Mouse; P=Porcine; Pr=Primate; R=Rat; Rb=Rabbit; Y=Yeast; Xe=Xenopus; Ze=Zebrafish; ; ; ; NA-Not Applicable; STP=Step-Tactin Proteins; All
Format: Affinity Purified - liquid
 
Immunogen: Peptide with sequence C-KDERFQLEEFS, from the internal region of the protein sequence according to NP_660339.1.
 
Description/Data:
Picture

Cell adhesion molecule 4, CADM4, Immunoglobulin superfamily member 4C, IGSF4C or NECL-4. An immunohistochemical study reveals that CADM4 is expressed at the cell-cell attachment sites in the renal tubules, the transitional epithelia of the bladder, and the glandular epithelia of the prostate.

Image: CADM4 (Dilution:2. 5μg/ml) staining of paraffin embedded Human Thymus. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.

CADM4 is also  in the telencephalic wall, whereas it becomes rather confined to the subplate, the cortical plate and the subventricular zone during development. It gradually decreases after birth and disappears in adulthood. It remains at low levels throughout embryonic stage. These spatiotemporal patterns of the expression suggest that CADM4 plays crucial roles in the development of both telencephalon and cerebellum. CADM is ectopically expressed in adult T-cell leukemia (ATL) cells, providing not only a diagnostic marker for ATL, but also a possible therapeutic target against its invasion.

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Image: Staining of Human Brain (Cerebellum) lysate (35µg protein in RIPA buffer) with CADM4. Primary incubation was 1 hour. Detected by chemiluminescence.