FE65

Affinity Purified Rabbit Antibody

DATASHEET (doc - 71Kb)

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Type: Rabbit IgG

Applications: WB

ICC=Immunocytochemistry; IF=Immunofluorescence; IHC=Immunohistochemistry; WB=Western blotting; FC=Flow Cytometry; IP=Immunoprecipitation; E=ELISA; NB=Neutralization of Bioactivity; FACS; FM=Fluorescent Micsroscopy; ; FPLC=Fast Protein Liquid Chromatography; GF=Gravity Flow; HPLC=High Performance Liquid Chromatography; TPE=Targeted Protein Expression; ; ; AC=Adherent Cell Assays; ; ; NAC=Non-adherent Cell Assays; ; ; BSC-CM5= Biacore Sensor Chip CM5; ;

Species Reactivity: H; M; R

B=Bovine; Ca=Cat; Ch=Chicken; D=Dog; EQ=Equine; GP=Guinea Pig; H=Human; M=Mouse; P=Porcine; Pr=Primate; R=Rat; Rb=Rabbit; Y=Yeast; Xe=Xenopus; Ze=Zebrafish; ; ; ; NA-Not Applicable; STP=Step-Tactin Proteins

Format: Affinity Purified - liquid

Immunogen: Peptide corresponding to residues surrounding Thr668 of human APP695

Description/Data:

Amyloid precursor protein (APP) plays a central role in the pathogenesis of Alzheimer's disease (AD). FE65 is a signaling adaptor of APP protein. The FE65/APP complex was shown to translocate into the cell nucleus and regulate gene expression. Genetic studies in mice validated FE65-APP interaction and molecular studies provided evidence on the role of the complex in abnormal signaling detected in brains of Alzheimer Disease patients.

Image: Western blot analysis using FE65 and HEK 293 cell lysates

Related Reagents to Consider:

ADAM10 (Human) (GT15078)

ADAM10 (Mouse) (GT15079)