|Catalog Number||Size||Price (USD)||Shopping Cart|
|RA25087||100 ug||$425.00||Buy Now | Add to Cart|
Mammalian target of rapamycin (mTOR) regulates cell growth, cell proliferation, cell motility, cell survival, protein synthesis, and transcription. It is is activated in response to nutrients, growth factors and cellular energy.
Image: mTOR (red) staining of L6 myotubes. Nuclei are stained with nuclear antigen antibody (green).
Dysregulated mTOR signaling has been implicated in major diseases These include: cancer, metabolic disorders, neurological diseases, and inflammation. For example, findings demonstrate mTOR signaling hyperactivity in Alzheimer's Disease (AD) brains.
Image: mTOR protein kinase assay: mTOR (dilution -1:1000) immunoprecipitates were incubated at 30°C with recombinant 4E-BP1 and 32P-gATP. Autoradiograph shows 32P incorporated into 4E-BP1.