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Type: Guinea Pig IgG
 
Applications: IHC
E=ELISA; FACS; FC=Flow Cytometry; FPLC=Fast Protein Liquid Chromatography; GF=Gravity Flow; HPLC=High Performance Liquid Chromatography; ICC=Immunocytochemistry; IF=Immunofluorescence; IHC=Immunohistochemistry; IP=Immunoprecipitation; NAC=Non-adherent Cell Assays; NB=Neutralization of Bioactivity; SE=Sandwich ELISA; TPE=Targeted Protein Expression; WB=Western blotting; ; AC=Adherent Cell Assays; FM=Fluorescent Micsroscopy; ; ; BSC-CM5= Biacore Sensor Chip CM5; BSM=Biosactive Small Molecule or Peptide; CDM=Cell Differentiation Media; ; ; ; ; ; Health and Fitness; ; ; DNA Extraction/Purification; ; In vivo Like Assays
Species Reactivity: M; R
B=Bovine; Ca=Cat; Ch=Chicken; D=Dog; EQ=Equine; GP=Guinea Pig; H=Human; M=Mouse; P=Porcine; Pr=Primate; R=Rat; Rb=Rabbit; Y=Yeast; Xe=Xenopus; Ze=Zebrafish; ; ; ; NA-Not Applicable; STP=Step-Tactin Proteins; All
Format: Affinity Purified - liquid
 
Immunogen: SQENPNTYSEDLDV. Corresponding to residues 235-248 of the rat proDynorphin.
 
Description/Data:
Image of ProDynorphin staining the Rat Supraoptic Nucleus

Dynorphin peptides are members of the opioid peptide family and contain the canonical opioid sequence Tyr-Gly-Gly-Phe. These peptides are derived from prodynorphin and include dynorphin A, dynorphin B and alpha neo-endorphin. Of the opioid peptides, the dynorphins have the highest affinity for the kappa opioid receptor. They are found distributed throughout the nervous system and play a role in many physiological functions.

Please note: Dr Patrick Mantyh et al have successfully used this antibody to stain mouse spinal cord tissue. see J Pain Symptom Manage. 2008 September; 36(3): 289–303.

Pro-Dynorphin: Customer Publications

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Images: Systemic artemin normalized immunohistochemical markers in the ipsilateral L5 DRG, dorsal spinal cords and sciatic nerves of SNL rats.Immunofluorescent labeling was done 14 d after sham or SNL surgery and treatment with vehicle or artemin starting on day 3 after surgery. Scale bar = 100 um for DRG (first two rows), 50 mum for sciatic nerve (third row) and 200 mum for spinal cord (bottom row). Nature Medicine  9, 1383 - 1389 (2003); doi:10.1038/nm944 ...guinea-pig antibody to prodynorphin (1:10,000; Neuromics). Secondary antibodies were Alexa Fluor 594−conjugated goat antibody to guinea-pig IgG (1:1,000; Molecular Probes)...

Image of ProDynorphin immufluorescence staining of dorsal spinal cords and sciatic nerves of SNL rats

Image: Immuofluorescent detection of Prodynorphin (seen as immunoreactive varicosities) in art hypothalamus (red fluorescence).