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Type: Mouse IgG
 
Applications: IF; IHC; IP; WB
E=ELISA; FACS; FC=Flow Cytometry; FPLC=Fast Protein Liquid Chromatography; GF=Gravity Flow; HPLC=High Performance Liquid Chromatography; ICC=Immunocytochemistry; IF=Immunofluorescence; IHC=Immunohistochemistry; IP=Immunoprecipitation; NAC=Non-adherent Cell Assays; NB=Neutralization of Bioactivity; SE=Sandwich ELISA; TPE=Targeted Protein Expression; WB=Western blotting; ; AC=Adherent Cell Assays; FM=Fluorescent Micsroscopy; ; ; BSC-CM5= Biacore Sensor Chip CM5; BSM=Biosactive Small Molecule or Peptide; CDM=Cell Differentiation Media; ; ; ; ; ; Health and Fitness; ; ; DNA Extraction/Purification; ; In vivo Like Assays
Species Reactivity: M; R
B=Bovine; Ca=Cat; Ch=Chicken; D=Dog; EQ=Equine; GP=Guinea Pig; H=Human; M=Mouse; P=Porcine; Pr=Primate; R=Rat; Rb=Rabbit; Y=Yeast; Xe=Xenopus; Ze=Zebrafish; ; ; ; NA-Not Applicable; STP=Step-Tactin Proteins; All
Format: Affinity Purified - liquid
 
Immunogen: Synthetic peptide amino acids 209 –225 (extracellular S1-S2 loop) of rat Kv4.2 (CGSSPGHIKELPSGERY; accession number Q63881).
 
Description/Data:
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Kv4.2 K+ Channels contribute to the cardiac transient outward potassium current, the main contributing current to the repolarizing phase 1 of the cardiac action potential. Kv4.2 knockout are more sensitive to pain than normal mice and increased reactivity to novel stimulus such as an auditory tone.

Image: Adult WT and Kv4.2-/- mouse double immunofluorescence staining anti-Kv4.2 (red) and rabbit polyclonal anti-Kv2.1 (green).

Note: Antibody has been developed by UC Davis under a grant by NIH.

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Image: Kv4.2 western blots of membrane fractions of whole rat brain. (A) Dilution 1:100 (B) Dilution\.