LepRb/OBRb

Affinity Purified Chicken Antibody
DATASHEET(pdf - 452Kb)
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Applications: IF; IHC; WB
E=ELISA; FC=Flow Cytometry; ICC=Immunocytochemistry; IF=Immunofluorescence; IP=Immunoprecipitation; IHC=Immunohistochemistry; SE=Sandwich ELISA; WB=Western blotting; NB=Neutralization of Bioactivity; FACS; FPLC=Fast Protein Liquid Chromatography; GF=Gravity Flow; BSM=Biosactive Small Molecule or Peptide; HPLC=High Performance Liquid Chromatography; TPE=Targeted Protein Expression; AC=Adherent Cell Assays; NAC=Non-adherent Cell Assays; CDM=Cell Differentiation Media; BSC-CM5= Biacore Sensor Chip CM5; FM=Fluorescent Micsroscopy; ; ; ; ; ; ; ; ; ;
Species Reactivity: R
B=Bovine; Ca=Cat; Ch=Chicken; D=Dog; EQ=Equine; GP=Guinea Pig; H=Human; M=Mouse; P=Porcine; Pr=Primate; R=Rat; Rb=Rabbit; Y=Yeast; Xe=Xenopus; Ze=Zebrafish; ; ; ; NA-Not Applicable; STP=Step-Tactin Proteins; All
Format: Affinity Purified - liquid
 
Immunogen: Recombinant Protein
 
Description/Data:
Picture

Leptin is produced by adipose tissue and interacts with six types of receptor (LepRa–LepRf). LepRb is the only receptor isoform that contains active intracellular signaling domains. This receptor is present in a number of hypothalamic nuclei, where it exerts its effects.

It is also expressed in carotid bodies and plays a role in sleep apnea see: http://ir.lib.uwo.ca/cgi/viewcontent.cgi?article=2487&context=etd

Image: LepRb staining in rat intestine.Detection was done using anti-chicken Cy2 conjugated antibodies (green color). Cell nuclei were counterstained with DAPI (blue color). Working dilution is 1:200-1:600. 

LepRB/OBRb: Customer Publications

More Links:

Leptin Proteins 

Diabetes and Obesity Research Antibodies

Diabetes and Obesity Proteins

Immune Response Research Proteins

Leptin Recombinant Proteins 

 

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Images: Fluorescent (a-c) photomicrographs showing the effect of IH on Ob-Rb (a) and ERK 1/2 (b) expression in carotid body glomus cells. Note that Ob-Rb and ERK 1/2 are co-expressed in the same cells (c). Calibration mark in (a) represents 100 μm and applies to (a-c).

Picture[2]

 

Image:OB-Rb staining of 40 µm free-floating rat brainstem fixed with 4% paraformaldehyde. 1:50 dilution using Rhodamine Red-X, Donkey anti-Chicken for the secondary antibody.  Courtesy of Montina Van Meter (Dr’s. Rogers & Hermann - Autonomic Neuroscience Lab, Pennington Biomedical Research Center, Baton Rouge, LA).