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| Catalog Number | Size | Price (USD) | Shopping Cart |
|---|---|---|---|
| GT15150 | 100 ug | $365.00 | Buy Now | Add to Cart |
PDGF isoforms exert their cellular effect by binding to the structurally similar receptor tyrosine kinases (RTKs), PDGF R alpha and PDGF R beta. PDGF-AA, PDGF-BB, PDGF-CC, PDGF-DD and PDGF-AB isofoms bind the two distinct cell surface PDGF receptors with different affinities. Both PDGF R alpha and PDGF R beta are members of the class III subfamily of receptor tyrosine kinases (RTK). All class III RTKs are characterized by the presence of five immunoglobulin-like domains in their extracellular region and a split kinase domain in their intracellular region. PDGF binding induces receptor homo-and heterodimerization leading to signal transduction. The expression of alpha and beta receptors are independently regulated in various cell types.
Image: PDGF Staining in Rα in cryostat tissue sections of mouse embryo (13 d.p.c.) using 15 µg/mL of PDGF R Alpha. Tissues were stained using HRP-DAB (red-brown) and counterstained with hematoxylin (blue).
PDGF has also been linked to atherosclerosis, fibrosis and malignant diseases.
PDGF R Alpha/CD140A Customer Publications-(for staining of Oligodendrocyte Lineage (OL) Cells see 10.1016/j.ajpath.2011.09.018.