SMC1

Mouse Monoclonal Antibody

Catalog Number	Size	Price (USD)	Shopping Cart
MO15108	100 ug	$255.00	Buy Now \| Add to Cart

Type: Mouse IgM

Applications: IHC; WB; FC; E

ICC=Immunocytochemistry; IF=Immunofluorescence; IHC=Immunohistochemistry; WB=Western blotting; FC=Flow Cytometry; IP=Immunoprecipitation; E=ELISA; NB=Neutralization of Bioactivity; FACS; FM=Fluorescent Micsroscopy; ; FPLC=Fast Protein Liquid Chromatography; GF=Gravity Flow; HPLC=High Performance Liquid Chromatography; TPE=Targeted Protein Expression; ; ; AC=Adherent Cell Assays; ; ; NAC=Non-adherent Cell Assays; ; ; BSC-CM5= Biacore Sensor Chip CM5; ;

Species Reactivity: H; M; Pr; R

B=Bovine; Ca=Cat; Ch=Chicken; D=Dog; EQ=Equine; GP=Guinea Pig; H=Human; M=Mouse; P=Porcine; Pr=Primate; R=Rat; Rb=Rabbit; Y=Yeast; Xe=Xenopus; Ze=Zebrafish; ; ; ; NA-Not Applicable; STP=Step-Tactin Proteins

Format: Protein G Purified - liquid

Description/Data:

Structural Maintenance of Chromosome 1 (SMC1) is an ATPase which, with SMC3, forms a heterodimeric complex. These dimers form a V-shaped molecule with two long coiled-coil arms, each having an ATP-binding domain at its distal end. The SMC1/SMC3 heterodimer plays an important role in sister chromatid cohesion during metaphase, associates with the nuclear matrix and centrosome during interphase and localizes to kinetochores, spindles and spindle poles during mitosis. Smc1 is also a component of the DNA damage response and participates in the cellular response to DNA damage through its phosphorylation on Ser 957 and 966.

Inhibition of SMC1 is associated with chromosomal aberrations. These aberration play a role in developmental disorders like autism.

Image: Detection of SMC1 in Western Blot. Extracts from exponentially growing U2-OS (human), Balb/c-3T3 (mouse), and normal rat kidney (NRK) cells were prepared, resolved by SDS-PAGE, and transferred to a PVDF membrane. The membrane was immunoblotted with 0.25 μg/mL monoclonal anti-SMC1 antibody.

Other Reagents to Consider:

All Stem Cell Reagents

Proteins:

Transforming Growth Factors

Antibodies:

Neurotrophins/Growth Factors

Neuron/Glial Markers

Diabetes/Obesity Antibodies