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Extracellular ATP interacts with specific ionotropic (P2X) or metabotropic (P2Y) membrane receptors having different molecular characteristics. Discrete cell-specific expression of various subtypes of ATP receptors allows specificity and selectivity of purinergic responses in many body organs. At single cell level, the ATP effects are susceptible to modulation by crosstalk with other receptors and by intracellular molecular pathways, allowing refinement and plasticity of cell responses. ATP and related nucleotides are now recognized key players in many tissue and cell responses during physiological states or disease conditions, like in chronic pain, inflammation, neurologic disorders and cancer. By Elsa Fabbretti, University of Nova Gorica and user of these antibodies. 

Image: Double immunofluorescence staining in cultured human bladder urothelial cells (BUCs). BUCs show cytokeratin (red areas) and P2X3 (green areas) expression. Data Courtesy of Dr. Yan Sun University of Maryland School of Medicine Baltimore

NameCatalog #TypeSpeciesApplicationsSizePrice
P2X1RA10107Rabbit IgGRICC; IHC50 ul
150 ul
20 ug Blocking Peptide
$145
$348
$95
P2X2GP14106Guinea Pig IgGH; RICC; IHC; WB50 ul
150 ul
100 ug Blocking Peptide
$155
$348
$95
P2X2RA10108Rabbit IgGH; Pr; RICC; IHC; WB50 ul
150 ul
100 ug Blocking Peptide
$155
$348
$95
P2X3RA10109Rabbit IgGH; Pr; RFC; ICC; IHC; WB50 ul
150 ul
100 ug Blocking Peptide
$145
$348
$95
P2X3GP10108Guinea Pig IgGRIHC100 ul
100 ug Blocking Peptide
$395
$95
P2X3-PureRA14139Rabbit IgGH; Pr; RFC; ICC; IHC; WB100 ul
100 ug Blocking Peptide
$350
$95
P2Y2RA14103Rabbit IgGH; M; RIHC; WB100 ul
50 ug Blocking Peptide
$395
$95
P2YR8RA30005Rabbit IgGHIHC50 ug$425