|Catalog Number||Size||Price (USD)||Shopping Cart|
|RA25091||100 ul||$295.00||Buy Now | Add to Cart|
|RA25091H||50 ul @ 1 mg/ml||$325.00||Buy Now | Add to Cart|
|P25091||50 ug Blocking Peptide||$95.00||Buy Now | Add to Cart|
Cripto-1 (CR-1), also known as Teratocarcinoma-derived growth factor 1 (TDGF1), is a member of the epidermal growth factor (EGF)-GFC family and has been implicated in both embryogenesis and carcinogenesis. During early vertebrate development, CR-1 functions as a co-receptor for Nodal, a transforming growth factor b (TGFb) family member, and is essential for mesoderm and endoderm formation and anterior-posterior and left-right axis establishment. In adult tissues, CR-1 is expressed at a low level in all stages of mammary gland development, and expression increases during pregnancy and lactation.
Images:Immunocytochemistry/Immunofluorescence: Cripto1 antibody was tested in HeLa cells with Dylight 488 (green). Nuclei were counterstained with DAPI (blue) and tubulin was stained with alpha tubulin (red).
Over-expression of CR-1 in mouse mammary epithelial cells leads to their transformation in vitro, and when injected in mammary glands, CR-1 produces ductal hyperplasias.
Right Image: Western blot analysis of Cripto1 in MDA-MB231 lysates.
Left Images: FACS staining of NTERA-2 cells using Cripto1 antibody at a 1:50 dilution detected using Dylight-488 conjugated goat anti-rabbit IgG secondary