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Type: Rabbit IgG
 
Applications: ICC; IF; IP; WB
E=ELISA; FACS; FC=Flow Cytometry; FPLC=Fast Protein Liquid Chromatography; GF=Gravity Flow; HPLC=High Performance Liquid Chromatography; ICC=Immunocytochemistry; IF=Immunofluorescence; IHC=Immunohistochemistry; IP=Immunoprecipitation; NAC=Non-adherent Cell Assays; NB=Neutralization of Bioactivity; SE=Sandwich ELISA; TPE=Targeted Protein Expression; WB=Western blotting; ; AC=Adherent Cell Assays; FM=Fluorescent Micsroscopy; ; ; BSC-CM5= Biacore Sensor Chip CM5; BSM=Biosactive Small Molecule or Peptide; CDM=Cell Differentiation Media; ; ; ; ; ; Health and Fitness; ; ; DNA Extraction/Purification; ; In vivo Like Assays
Species Reactivity: H; M
B=Bovine; Ca=Cat; Ch=Chicken; D=Dog; EQ=Equine; GP=Guinea Pig; H=Human; M=Mouse; P=Porcine; Pr=Primate; R=Rat; Rb=Rabbit; Y=Yeast; Xe=Xenopus; Ze=Zebrafish; ; ; ; NA-Not Applicable; STP=Step-Tactin Proteins; All
Format: Affinity Purified - liquid
 
Immunogen: A synthetic peptide made to an N-terminal portion of the human JARID2 or jumonji protein sequence (between residues 1-100).
 
Description/Data:
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JARID2 or the Jumonji protein is a PRC2 component in embryonic stem cells required for multi-lineage differentiation and recruitment of PRC1 and RNA Polymerase II to developmental regulators. It is essential for embryogenesis, including neural tube formation. It plays a key role in differentiation of embryonic stem cells and normal development. Defects in JARID2, characterized by PRC1 and PRC2 mutants, show a severely compromised capacity for successful differentiation towards neural or mesodermal fates 

Images: JARID2 staining of HeLa cells using a DyLight 488 conjugated secondary antibody.

JARID2 is an excellent marker for studying differentiation patterns in induced pluripotent stem cells (iPSCs) and embyonic stem cells (eSCs).

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Images: Western blot detection of JARID2 protein in E16 mouse brain lysates.