Calcineurin A, also known as PP2B and PPP3CA, is the 59 kDa catalytic subunit of the calcium/calmodulin-dependent protein phosphatase. When activated by calcium in the presence of the regulatory B subunit and calmodulin, Calcineurin A selectively removes phosphates from serine and threonine residues on target proteins. Although ubiquitously expressed, Calcineurin levels are highest in brain, where the phosphatase plays a role in the formation and retention of memories.
Image:Recombinant human Calcineurin A (1 ng) and lysates prepared from human HT29, mouse TS1, and rat Nb2-11 cells were resolved by SDS-PAGE, transferred to an Immobilon-P membrane, and immunoblotted with 1 μg/mL anti-Calcineurin A, as described on datasheet. A ten second exposure to film is shown.