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Testimonial: "I am glad I've found Neuromics and purchased your cells. They look great and we'll make good use of them. They are valuable tool for us and for others I am sure, as they represent a unique product on the market.", Caroline, Large Biopharma

We are pleased to introduce our Cancer-Associated Fibroblasts (CAFS). CAFs are closely associated with primary tumor cells and participate in the neoplastic process. There is reciprocal communication between CAFs and tumor cells through paracrine effects of secreted growth factors, cytokines & chemokines from both fibroblasts, tumor cells and other tumor-associated cells.

Image: Kinetic tox assay using Pancreatic Tumor Cells

CAFs may be derived from MSCs and MSCs may also promote CAF proliferation through Wnt and TGF-b signaling. Thus, our well-characterized human MSCs (catalog number SC00A1) may be used in conjunction with CAFs to further elucidate the relationship between MSCs and CAFs. CAFs therefore represent another potential target for cancer therapy and enhanced understanding of tumor growth, angiogenesis and metastasis.

We currently have available ready to culture endometrial Adeno-Carcinoma and Ovarian Serous Tumor CAFs. CAFs from other human tumor types are available on request including lung, kidney and other ovarian tumors. For more information contact Pete Shuster @ pshuster@neuromics.com or 612-801-1007.

CELL LINES

CD105

CD90

CD44

CD326

CD133

FAP

SC00A1 (hMSCs)

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-

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SC00A5 (pancreatic fibroblasts)

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-

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CAF05 (colorectal CAFs)

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-

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CAF07-AD (adenocarcinoma lung CAFs)

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CAF08 (Pancreatic Stellate CAFs)

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Table: Expression of key proteins by cell lines

NameCatalog #TypeSpeciesApplicationsSizePrice
Human Breast CAFsCAF06Human Primary CAFsHCell Assays1,000,000 cells$1,779
Human Colorectal Tumor CAFsCAF05Human Primary CAFsHCell Assays1,000,000 cells$799
Human Endometrial Adenocarcinoma CAFsCAF01Human Primary CAFsHCell Assays1,000,000 cells$799
Human Ovarian Serous Tumor CAFsCAF02Human Primary CAFsHCell Assays1,000,000 cells$799
Human Lung Adenocarcinoma CAFsCAF07AHuman Primary CAFsHCell Assays1,000,000 cells$799
Human Lung Squamous Cell Tumor CAFsCAF07SCHuman Primary CAFsHCell Assays1,000,000 cells$799
Human Melanoma CAFsCAF09Human Primary CAFsCell Assays1,000,000 cells$899
Human Immortalized Pancreatic CAF-Stellate CellsCAF08Human Primary CAFsHCell Assays1,000,000 Immortized Cells$1,550
Human Pancreatic Tumor Cells KitPXPC3A1Cells+Media KitHCell Assays1,000,000 cells$499
Conditioned Media for Ovarian Serous Tumor CAFSCAF04Cell Growth MediaHCell Assays5 ml$250
Conditioned Media from Endometrial CAFSCAF03Cell Growth MediaHCell Assays5 ml$250
VitroPlus III, low serum, completePC00B1-500Cell Growth Media500 ml$184
Pancreatic Stellate CAF Maintaining MediaPC00B5-500Cell Growth Media500 ul$195