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Type: Protein
 
Species Reactivity: R
B=Bovine; Ca=Cat; Ch=Chicken; D=Dog; EQ=Equine; GP=Guinea Pig; H=Human; M=Mouse; P=Porcine; Pr=Primate; R=Rat; Rb=Rabbit; Y=Yeast; Xe=Xenopus; Ze=Zebrafish; ; ; ; NA-Not Applicable; STP=Step-Tactin Proteins; All
Description/Data:

MAG (MyelinAssociated Glycoprotein), a type I transmembrane glycoprotein containing five Ig like domains in its extracellular domain is an adhesion molecule belonging to the immunoglobin superfamily. MAG is expressed on myelinating oligodenrocytes and Schwann cells, and preferentially recognizes α2, 3linked sialic acid on Olinked glycans and gangliosides. MAG exists as two isoforms which differ in the sequence and length of the cytoplasmic tail. The large form (71 kDa) and small form (67 kDa) arise from alternative spliced mRNAs. Although MAG might encounter haematopoietic cells and lymphocytes under pathologic conditions, it would normally be expected to interact with neuronal cells. It has been shown that MAG promotes axonal growth from neonatal DRG neurons and embryonic spinal neurons, but is a potent inhibitor of axonal regrowth from adult DRG and postnatal cerebellar neurons. MAG plays an important role in the interaction between axons and myelin. A soluble form of MAG containing the extracellular domain is released from myelin in large quantities and identified in normal human tissues and in tissues from patients with neurological disorders. This soluble MAG might contribute to the lack of CNS neuron regeneration after injury.

References:
1. Kelm, S. et al. (1994) Current Biology 4:965.
2. McKerracher, L. et al. (1994) Neuron 13:805.
3. Tang, S. et al. (1997) Molecular and Cellular Neuroscience 9:333. 4. Cai, D. et al. (1999) Neuron 22:89.