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699-1010 mg$159.00Buy Now | Add to Cart
910-501 mg$609.00Buy Now | Add to Cart
 
Type: Ligand
 
Applications: BSM
E=ELISA; FACS; FC=Flow Cytometry; FPLC=Fast Protein Liquid Chromatography; GF=Gravity Flow; HPLC=High Performance Liquid Chromatography; ICC=Immunocytochemistry; IF=Immunofluorescence; IHC=Immunohistochemistry; IP=Immunoprecipitation; NAC=Non-adherent Cell Assays; NB=Neutralization of Bioactivity; SE=Sandwich ELISA; TPE=Targeted Protein Expression; WB=Western blotting; ; AC=Adherent Cell Assays; FM=Fluorescent Micsroscopy; ; ; BSC-CM5= Biacore Sensor Chip CM5; BSM=Biosactive Small Molecule or Peptide; CDM=Cell Differentiation Media; ; ; ; ; ; Health and Fitness; ; ; DNA Extraction/Purification; ; In vivo Like Assays
Species Reactivity: All
B=Bovine; Ca=Cat; Ch=Chicken; D=Dog; EQ=Equine; GP=Guinea Pig; H=Human; M=Mouse; P=Porcine; Pr=Primate; R=Rat; Rb=Rabbit; Y=Yeast; Xe=Xenopus; Ze=Zebrafish; ; ; ; NA-Not Applicable; STP=Step-Tactin Proteins; All
Description/Data:
Picture[2]

Biological Activity

The most κ/μ-selective and among the most potent κ ligands known (25 times more potent than morphine in vivo).

(±)-1-(3,4-Dichlorophenyl)acetyl-2-(­1-pyrrolidinyl)methylpiperidine hydrochloride

Certificate of Analysis and Safety Data Sheet

BRL 52537 hydrochloride

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Figure: Infarct volume after 3 days of reperfusion in the ipsilateral cortex and CP complex in male rats treated with vehicle saline (n=15) or 1 mg/kg per hour BRL 52537 (n=15) started at onset of reperfusion and continued for 22 hours (male-vehicle n=15; male-BRL n=15; mean±SEM). *P<0.05 vs male vehicle controls. doi: 10.1161/01.STR.0000169928.76321.3d