Leukemia Inhibitory Factor (LIF) is a lymphoid factor which promotes long-term maintenance of embryonic stem cells by suppressing spontaneous differentiation. LIF has a number of other activities including cholinergic neuron differentiation, control of stem cell pluripotency, bone and fat metabolism, mitogenesis of certain factor dependent cell lines and promotion of megakaryocyte production in vivo. Human LIF is a 19.7 kDa protein containing 181 amino acid residues. The non-glycosylated, E. coli expressed, recombinant human LIF is indistinguishable from native LIF in its biological activities in vitro. Human and murine mature LIF exhibit a 78% sequence identity at the amino acid control. Human LIF is equally active on both human and mouse cells. Murine LIF is approximately 1000 fold less active on human cells, than hLIF.
Stem Cell Workflow Stage:
- Product ReviewsGreat customer service and everything went smooth with the order. Product Name: hNP1 Human Neural Progenitor Expansion Kit - (Cat# HN60001) http://bit.ly/1hbpCkD Product Name: Leukemia Inhibitory Factor (LIF), Recombinant Protein - (Cat# PR16101) http://bit.ly/1s7NZe3 Product Name: Recombinant Human FGF basic (146 aa), Recombinant Protein - (Cat# PR15002CF) http://bit.ly/1TT74K3 Organization: Halyard HealthC. Caesar - May 13, 2016 - Rating: 4.0
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