Transcription factors are proteins involved with the gene regulation, and include the distinct feature of having DNA-binding domains allowing them to bind to specific sequences of DNA. Transcription factors play a role in the expression of genes in different cell types and during development.
Our selection of transcription factor antibodies include antibodies in the follow family: FOX, HIFs, SOX and STAT.
FOX or Forkhead box Proteins are a family of transcriptional regulators that are defined by a conserved 100-amino acid DNA-binding domain. They regulate diverse cellular processes including differentiation, metabolism, development, proliferation, and apoptosis. Many are involved in embyrogensis and organogenesis. This includes the regulation of stem cells and progenitors.
The misregulation and/or mutation of FOX genes often induce human genetic diseases, promote cancer or deregulate ageing. Indeed, germinal FOX gene mutations cause diseases ranging from infertility to language and/or speech disorders and immunological defects.
Name Catalog # Type Species Applications Size Price FOXC1 GT41004 Goat IgG Human, Mouse WB, IHC 100 ug $250.00 FOXD3 RA25044 Rabbit IgG Human, Mouse WB, IHC 100 ug $365.00 FOXE1 GT41017 Goat IgG Human IHC, E 100 ug $310.00 FOXN1 GT41016 Goat IgG Human IHC, E 100 ug $250.00 FOXP2 GT41022 Goat IgG Human, Rat WB, IHC 100 ug $250.00 FOXP3/Scurfin GT41002 Goat IgG Human IHC 100 ug $250.00 HNF-3beta/FoxA2 GT15186 Goat IgG Human WB, IHC, E 100 ug $365.00
Hypoxia contributes significantly to the pathophysiology of major categories of human disease, including myocardial and cerebral ischemia, cancer, pulmonary hypertension, congenital heart disease and chronic obstructive pulmonary disease
HIFs (Hypoxia-inducible factors) respond to changes in available oxygen, especially hypoxia. They are critical for mainting oxygen homeostasis and preventing hypoxia. They are also vital to development. In mammals, deletion of the HIF-1 genes results in perinatal death. HIF-1 has been shown to be vital to chondrocyte survival, allowing the cells to adapt to low-oxygen conditions within the growth plates of bones.
Name Catalog # Type Species Applications Size Price Factor Inhibiting HIF-1/FIH RA25046 Rabbit IgG Mouse, Rat ICC, WB, IHC 100 ul $385.00 HIF Prolyl Hydroxylase 2 MO25046 Mouse IgG Human WB, IHC 100 ul $325.00 HIF-1 alpha RA25066 Rabbit IgG Human, Primate WB 100 ul $325.00 HIF-2 alpha Biotin MO25044B Mouse IgG Human, Mouse, Rat WB, IHC 100 ul $345.00 HIF-3 alpha RA25075 Rabbit IgG Mouse WB 100 ul $325.00
The developmentally important Sox family has no singular function, and many members possess the ability to regulate several different aspects of development. While many Sox genes are involved in sex determination, some are also important in processes such as neuronal development. For example, Sox2 and Sox3 are involved in the transition between epithelial granule cells in the cerebellum to their migratory state. Granule cells then differentiate to granule neurons, with Sox11 being involved in this process. It is thought that some Sox genes may be useful in the early diagnosis of childhood brain tumours due to this sequential expression in the cerebellum, making them a target for significant research
Name Catalog # Type Species Applications Size Price SOX1 GT15208 Goat IgG Human WB, IHC, E 100 ug $365.00 SOX10 GT15218 Goat IgG Human WB, IHC, E 100 ug. $365.00 SOX10 MO15116 Mouse IgG Human, Rat ICC, IHC 100 ug $255.00 SOX17 GT15094 Goat IgG Human ICC, WB, E 100 ug $365.00 SOX2 GT15098 Goat IgG Human WB, IHC, E 100 ug. $375.00 SOX2 MO15040 Mouse IgG Human WB, IHC 100 ug $255.00 SOX2 RA25021 Rabbit IgG Human, Mouse ICC, WB, IHC 100 ul $275.00 SOX21 GT15209 Goat IgG Human, Mouse WB, IHC, E 100 ug $365.00 SOX3 GT15119 Goat IgG Human ICC, WB, E 100 ug $365.00 SOX6 RA19023 Rabbit IgG Human, Mouse, Rat, Primate WB, IHC 100 ug $225.00 SOX7 MO15050 Mouse IgG Human WB, E 100 ug $255.00 SOX7 MO15050 Mouse IgG Human WB, E 50 ug $89.00 SOX9 GT15207 Goat IgG Human WB, IHC, E 100 ug $365.00
Signal Transducer and Activator of Transcription (STAT) family proteins mediate cytokine signaling by acting as signal transducers in the cytoplasm and transcription activators in the nucleus. STAT6 is important for the development of Th2 cells and regulation of gene expression induced by IL-4 and IL-13.