This gene belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. It plays a role in the differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues.
Defects in FOXP2 are the cause of speech-language disorder 1 (SPCH1); also known as autosomal dominant speech and language disorder with orofacial dyspraxia. Affected individuals have a severe impairment in the selection and sequencing of fine orofacial movements, which are necessary for articulation
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