The processes of angiogenesis and neurogenesis show striking similarities. Given our strong roots in providing Neuroscience research reagents, it is a natural extension for us to provide potent reagents for the studying the growth of new blood vessels.
Angiogensis processes are important for healing wounds and for restoring blood flow to tissues after injury or insult. In females, it also occurs during the monthly reproductive cycle and during pregnancy(to build the placental circulation between mother and fetus.
Angiogenesis-dependent diseases result when new blood vessels either grow excessively or insufficiently. These disease include: cancers, diabetic blindness, age-related macular degeneration, rheumatoid arthritis, psoriasis, neurodegeneration and many more.
- Angiogenic Growth Factors
Angiogenic growth factors are naturally occurring compounds that stimulate blood vessel growth. In a normal, healthy human angiogenic growth factors are produced in balance with angiogenesis inhibitors and therefore there is no blood vessel growth. When growth factors are produced in excess of inhibitors, blood vessel growth will occur.
These growth processes are important for vascularization in wound healing and restoring blood flow to damaged tissue. They are also the root cause of many diseases and patthologies.
Name Catalog # Type Species Applications Size Price Angiopoietin-1 (ANG-1) RA26000 Rabbit IgG Human, Mouse, Rabbit WB, IHC 100 ul $375.00 FGF-2 MO27001 Mouse IgM Human WB, E, IP 500 ug $395.00 KDR (Kinase Insert Domain Receptor) RA21018 Rabbit IgG Human ICC, WB, IHC, IF 50 ug $345.00 Leptin RA30011 Rabbit IgG Mouse WB, IHC, E 50 ug $435.00 Leptin RA21019 Rabbit IgG Human, Mouse, Rat ICC, WB, IHC, IF 50 ug $345.00 TGF beta MO20012 Mouse IgM Human IHC 100 ul. $150.00 TGF beta RI (type1) MO20011 Mouse IgM Human IHC 100 ul. $250.00 VEGF R2 (FLK1/KDR) RA25011 Rabbit IgG Human, Mouse, Rat IHC 100 ul $425.00 VEGF R2 (FLK1/KDR) RA25011 Rabbit IgG Human, Mouse, Rat IHC 500 ul $465.00 VEGF R3 (Flt-4) MO20013 Mouse IgG Human IHC 100 ul $150.00 VEGF-D RA26005 Rabbit IgG Human, Mouse, Rat, Rabbit WB, IHC 100 ul $375.00
- Endothelial Cell Markers
Endothelial cells line the interior of all blood vessels and are typically one of the most quiescent cell types in the body. These cells are derived from a common angioblast precursor and subsequently develop organ specific properties. Although embryonic endothelial cells exhibit much heterogeneity within and between organs, multiple proteins expressed by endothelial cells can be used to distinguish these cells from other cell types in the body. Differentiation of endothelial cells is governed by several factors, including the immediate micro-environment, interactions with surrounding cells, and the local release of cytokines and growth factors
Name Catalog # Type Species Applications Size Price CD34/HPCA1 MO18004 Mouse IgG Human IHC 100 ul $399.00 CD34/HPCA1 MO20026 Mouse IgG Human IHC 100 ul $155.00 EMAP II RA34002 Rabbit IgG Human WB, E 100 ul $299.00 KDR (Kinase Insert Domain Receptor) RA21018 Rabbit IgG Human ICC, WB, IHC, IF 50 ug $345.00 LYVE-1 RA25047 Rabbit IgG Mouse WB, IHC 100 ul $285.00 VEGF R2 (FLK1/KDR) RA25011 Rabbit IgG Human, Mouse, Rat IHC 100 ul $425.00 VEGF R2 (FLK1/KDR) RA25011 Rabbit IgG Human, Mouse, Rat IHC 500 ul $465.00 VEGF R3 (Flt-4) MO20013 Mouse IgG Human IHC 100 ul $150.00 ZO1 RA34004 Rabbit IgG Human WB, IHC, FC, IF 100 ul $459.00
- ILs, CCRs, CXCs, MIPs and STATs
These belong to the broad category of cytokines and chemokines. The related proteins play a role in growth, differentiation, and activation functions that regulate and determine the nature of immune responses and control immune cell trafficking and the cellular arrangement of immune organs. Which cytokines are produced in response to an immune insult determines initially whether an immune response develops and subsequently whether that response is cytotoxic, humoral, cell-mediated, or allergic.
- Intra-Cellular Signaling
Intracellular signaling pathways direct endothelial cell activities and ultimately promote or inhibit angiogenesis
Name Catalog # Type Species Applications Size Price HIF-1 alpha RA25066 Rabbit IgG Human, Primate WB 100 ul $325.00 HIF-2 alpha Biotin MO25044B Mouse IgG Human, Mouse, Rat WB, IHC 100 ul $345.00 SMAD-2 RA21025 Rabbit IgG Human, Mouse, Rat ICC, WB, IHC, IF 50 ug $275.00 SMAD3 RA30033 Rabbit IgG Human, Mouse, Rat, Chicken, Bovine, Porcine WB, IHC, E 50 ug $495.00
- Matrix Metalloproteinases (MMPs)
Matrix Metalloproteinases (MMPs) are a family of zinc metalloendopeptidases secreted by cells, and are responsible for much of the turnover of matrix components. They are produced as zymogens, with a signal sequence and propeptide segment that must be removed during activation. In general, This signal sequence and propeptide plus a catalytic domain (containing the highly conserved zinc binding site) characterizes the structure of the MMPs.
MMPs are considered to play an important role in wound healing, apoptosis, bone elongation, embryo development, uterine involution, angiogenesis and tissue remodeling, and in diseases such as multiple sclerosis, Alzheimer's, malignant gliomas, lupus, arthritis, periodontis, glumerulonephritis, atherosclerosis, tissue ulceration, and in cancer cell invasion and metastasis.
Name Catalog # Type Species Applications Size Price ADAM15 RA21008 Rabbit IgG Human, Mouse, Rat ICC, WB, IHC, IF 50 ug $345.00 MMP1 (Matrix Mellatopeptidase 1), N terminal region RA21020 Rabbit IgG Mouse ICC, WB, IHC, IF 100 ug $285.00 MMP2 (Matrix Mellatopeptidase 2), C terminal region RA21021 Rabbit IgG Human ICC, WB, IHC, IF 100 ug $285.00 MMP9 (Matrix Mellatopeptidase 9), N terminal region RA21022 Rabbit IgG Human, Mouse, Rat ICC, WB, IHC, IF 100 ug $235.00
- More Angiogenesis Research Antibodies
The Other Angiogenesis Research Antibodies
Name Catalog # Type Species Applications Size Price c-Myc RA25085 Rabbit IgG Human WB, IF 100 ul $355.00 Carcinoembryonic Antigen (CEA) MO47049 Mouse IgM Human IHC 0.5 ml $309.00 GATA3 MO47046 Mouse IgG Human IHC 100 ug $309.00 LMO2 (LIM-Only Transcription Factor 2) MO47033 Mouse IgG Human IHC 0.5 ml $309.00 Lysosomal Associated Membrane Protein 1 (LAMP1) MO22129 Mouse IgG Human ICC, WB, IHC, IF 100 ul $275.00
- Semaphorins and Plexins
Semaphorins are a class of secreted and membrane proteins that act as axonal growth cone guidance molecules. They primarily act as short-range inhibitory signals and signal through multimeric receptor complexes. They are usually cues to deflect axons from inappropriate regions, especially important in neural system development. The major class of proteins that act as their receptors are called plexins.
Two distinct transmembrane receptor families have been identified as Semaphorin receptors. Neuropilins provide binding specificity for the class 3 Semaphorins, whereas Plexins, which also contain a Sema domain serve as signaling partners for class 3 Semaphorins and as functional receptors for transmembrane Semaphorins.
Wnt proteins are key regulators of embryonic development. Many receptors and inhibitors influence the Wnt-signaling pathway to ultimately regulate beta-Catenin stability and availability. Understanding Wnt and beta-Catenin signaling and the role of their antagonists (including Frizzled proteins) is important to elucidating the events controlling stem cell organization and maintenance, embryonic development, tissue differentiation, cell adhesion and migration, as well as tumorigenesis and cancer induction and progression.
Name Catalog # Type Species Applications Size Price Dkk-1 GT30000 Goat IgG Human WB, IHC, E 50 ug $435.00 Frizzled 7 RA30031 Rabbit IgG Human, Mouse IHC 50 ug $435.00 Frizzled 9 RA30032 Rabbit IgG Human IHC 50 ug $435.00 Glypican-3 (GLP3) MO47069 Mouse IgG Human IHC 100 ul $309.00 Wnt10a RA30027 Rabbit IgG Human IHC 50 ug $435.00 Wnt2b RA30030 Rabbit IgG Human IHC 50 ug $435.00 Wnt5b RA30025 Rabbit IgG Human IHC 50 ug $435.00 Wnt8a RA30029 Rabbit IgG Human IHC 50 ug $435.00