Earlier this year, we highlighted when our human brain microvascular endothelial cells (HBMECs) (cat. no. HEC02) were published in COVID-19 research. Guess what??? They're back! This time in hypertension and diabetes research released earlier this month.

A collection of researchers from across Italy and the Albert Einstein College of Medicine published their findings a few weeks ago with the help of our HBMECs. Combining in vitro experiments using our cells with cognitive tests of hypertensive patients, these investigators demonstrated that hyperglycemia aggravates cognitive impairment. They also found that patients treated with metformin, a diabetic drug, performed better on the cognitive test than patients treated with insulin.

Image: HBMECs stained with Claudin-5.

Read more to check out the full publication...


  1. Pasquale Mone, Jessica Gambardella, Antonella Pansini, Antonio de Donato, Giuseppe Martinelli, Eugenio Boccalone, Alessandro Matarese, Salvatore Frullone, and Gaetano Santulli. (2021). Cognitive Impairment in Frail Hypertensive Elderly Patients: Role of Hyperglycemia.Cells, 10(8), 2115. doi: 10.3390/cells10082115
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