The latest news from Neuromics, customers, collaborators, and friends. Here we will post publications, data, new reagents, and methods.
For additional information on Neuroscience updates check out our Neuroscience Blog.
Another Pain Antibody Pub
A couple months ago, we published a blog post highlighting the 20+ years of results our pain antibodies have demonstrated (learn more here). It didn't take long into 2023 to add on another year to the total. Earlier this month, researchers from the University of Texas Health Science Center at San Antonio published preliminary findings with the help of Neuromics' Guinea Pig VR1 C-Terminus/TRPV1 antibody (cat. GP14100).
Image: Immunofluorescent images of WGA and TRPV1 (cat. GP14100) staining of TG tissues in male and female mice with colocalization of TRPV1 and WGA indicated with arrows.
The researchers noted that orofacial pain is clinically understood to be more common in females than males. However, despite this understanding, no research had been done to look at what factors cause this occurrence. Using mice as a model, the investigators began to characterized the sex-specific differences in gene expression, biological pathways, and molecular function of tongue sensory neurons. Our antibody played a big part in their analysis. We encourage you to check out the full publication below to learn more about their findings.
So Much FBS News to Share
Even though 2023 just started, it's already been a busy couple of weeks for our Fetal Bovine Serum (FBS) in a variety of ways. We've already released a new product, been cited in a publication, and brought back into stock a couple of our most popular FBS lines. Before we dive into the specifics, we should mention that you can explore all of our FBS options here along with at the bottom of the blog.
Starting with the new product, we are now offering Female-Only FBS (cat. FBS001-F). This serum is derived exclusively from the blood of female fetuses for those of you with specific applications in this area. We encourage you to check out the product to learn more.
Next up, there was research recently published referencing the use of our FBS for the culture of HEK-293 cells. Both our Premium USA Origin FBS (cat. FBS001) and Preferred FBS (cat. FBS007) were used by the researchers from Fordham University. The investigators explored the mechanisms behind the cellular internalization and the spreading of misfolded tau which has implications in Alzheimer's Disease. We suggest you read the full publication here. Additionally, you can find all citations using our FBS here.
BBB Organoids Grown Using Neuromics Cells
Researchers from the University of Copenhagen utilized human primary cells from Neuromics in newly published research. With the help of our Human Brain Microvascular Pericytes (cat. HMP104) and our Human Brain Astrocytes (cat. HMP202), the investigators were able to build 3D organoids mimicking the blood-brain barrier (BBB). Furthermore, they used our growth media (pericyte and astrocyte, respectively) to culture both cell types as well.
The scientists were looking into how spirochetes within the Borrelia burgdorferi sensu lato (s.l.) complex cross the BBB. The complex is associated with the tick-borne bacterial central nervous system infection lyme neuroborreliosis (LNB). The Borrelia spirochetes resulted in swelling and the loss of structural integrity of the BBB organoids. The results offer a better understanding of how LNB affects the central nervous system.
Image: BBB-organoids co-incubated with varios B. burgdorferi s.l. isolates. The image show carboxyfluorescein succinimidyl ester (CFSE stained), Borrelia in green, nuclei in blue (DAPI), and actin in red (phalloidin).
We encourage you to check out the full publication here. If you want to see other publications using our human cells, including our astrocytes and pericytes, they can be found here. And of course, explore all of our human cell types as well.
Research Proven Transfection Kits
While we spend most of our time talking about our human cells, antibodies, media, and fetal bovine serum (FBS), there is a lot more that Neuromics offers to researchers. This includes a variety of transfection kits with applications across a wide variety of focus areas and in experiments both in vitro and in vivo.
Our transfection kits include products specifically designed to be used with certain cell types and cell lines. We encourage you to explore our entire selection of kits here.
Like with our other products, our transfection kits are also research proven. For example, just a couple of months ago, researchers from the University of Georgia College of Pharmacy and Mercer University published new findings using our i-Fect siRNA Delivery Kit (cat. NI35150). i-Fect was used to knockout genes in the spinal cord of rats. The scientists' findings suggest a potential treatment for neuropathic pain.
Pain Antibodies With 20+ Years of Proven Results
Image: Mouse inferior olive stained with Neuromics guinea pig TRPV1 antibody (cat. GP14100) using Cy3-conjugated donkey anti-guinea pig secondary antibodies (red color) and DAPI (blue) as a nuclear counterstain.
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