Quemliclustat and chemotherapy with or without zimberelimab in metastatic pancreatic adenocarcinoma: a randomized phase 1 trial
Neuromics' Pancreatic CAFS used in Phase1 Trial
Adenosine Biology and Pancreatic Cancer and Tumor Microenvironment (TME)-https://doi.org/10.1038/s41591-026-04283-z
Researchers from Arcus Biosciences, UCLA, Columbia, Stephenson Cancer Center, MD Anderson Cancer Center, Sarah Cannon Research Institute, University of Wisconsin, and NYU Langone used Neuromics' Pancreatic Cancer-Associated Fibroblasts (CAFS) to conduct a Phase 1 Study.
"Quemliclustat and chemotherapy with or without Zimberelimab in metastatic pancreatic adenocarcinoma: a randomized phase 1 trial." https://doi.org/10.1038/s41591-026-04283-z
Elevated adenosine levels in the TME suppress inflammation and immune function, markedly limiting the ability of the immune system to destroy tumor cells.
Cells, Coatings, Media, and ECMs
iPSC-Derived Human Cells for Neuroscientists
Human Brain Microvascular Endothelial Cells Used to Study SVD.
Researchers at UK Dementia Research and Brain Sciences Institute, Imperial College London, London, UK used Neuromics' Human Brain Microvascular Endothelial Cells (HBMVECS or BECS) to study gene expression in Cerebral small vessel disease, and Alzheimer's disease.
In short, Cerebral small vessel disease (SVD) often coexists with Alzheimer’s disease (AD), and brain endothelial cells (BECs) express genes associated with AD risk. To examine how genetic risk intersects with neurovascular cell regulation, we mapped gene regulomes across human BECs, mural cells, and other brain cell types. We found that AD heritability is predominantly immune related, with modest enrichment in BECs.
Image: (A) Schematic of nuclei isolation and epigenomic profiling of brain cell types from resected and post-mortem cortical samples. (B) UCSC genome browser visualization of H3K27ac and H3K4me3 CUT&Tag at cell-type-specific marker gene loci.(C) EWCE analysis of cell-type-specific promoters for resected and post-mortem brain cell types and for primary pericytes and BECs in brain single-cell gene expression.5∗Benjamini-Hochberg-corrected q < 0.05; ∗∗Benjamini-Hochberg-corrected q = 0. (D) CAMERA analysis of cell-type annotations from brain single-cell gene expression5 using differential promoters from resected and post-mortem brain cell types.
Their important findings demonstrate a genetic rationale for drug prioritization. Importantly, the results present targets and potential avenues for therapeutic intervention in AD and SVD, which have the potential to lower dementia risk.
- Kevin Chris Ziegler, Aydan Askarova, Alexi Nott et al (2025). The Brain Neurovascular Epigenome and Its Association with Dementia. Neuron. doi: 10.1016/j.neuron.2025.10.001
Primary Human Astrocyte and Human Umbilical Cell (HUVES) Organoids
Yvonne Adams, Anja T.R. Jensen (University of Copenhagen) manufactured Organioids using Neuromics' Primary Human Astrocytes and Human Brain Microvascular Endothelial Cells to study Plasmodium falciparum erythrocyte membrane protein 1 variants induce cell swelling and disrupt the blood–brain barrier in cerebral malaria.
Cerebral malaria (CM) is caused by the binding of Plasmodium falciparum–infected erythrocytes (IEs) to the brain microvasculature, leading to inflammation, vessel occlusion, and cerebral swelling.
Image 1: 3D BBB spheroids are composed of three different cell types. (A) FACS histogram showing pericytes (NG2, neural/glial antigen 2), astrocytes (GFAP, glial fibrillary acidic protein), and human cerebral microvascular endothelial cells (hCMEC/D3 and CD31).
Image2: ICAM-1–enriched microvilli and transmigratory ring/docking structures on brain hCMEC/D3 endothelial cells. (A–C) hCMEC/D3 brain endothelial cells were incubated with parasites.
This is first time the presence of intact, mature P. falciparum IEs within brain microvascular endothelial cells both in vitro and in vivo. The data on the enhanced binding and internalization of IEs suggest that the same approach will be necessary to counteract not only the effects of cytoadhesion but also the subsequent contribution to potentially lethal brain swelling in CM.
More on 3-D "in-vivo" Like HuCell Models
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Human Primary Cells, iPSC Derived Cells & Cell Lines Continued...
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Endless Antibody Applications
We often highlight the countless areas of study that our antibodies can help researchers. We encourage you to check out all our primary antibodies here along with the many applications they've been used for here.
Now, the three most prominent and common uses for our antibodies are in cancer, neuroscience, and pain research. Well, what do you know? Already this month, new research has been released utilizing our antibodies in those three corresponding areas. We'd like to highlight those studies below.
Image: Staining of various glioblastoma cell lines with Neuromics Humanin antibody (cat. RA19000).
In the first study, Korean researchers used our Humanin rabbit polyclonal antibody (cat. RA19000) to study glioblastoma progression. In their release of preliminary research, the investigators found humanin to encourage glioblastoma progression via the integrin alpha V (ITGAV)–TGF beta (TGF) signaling axis. Read the full publication here.
