The latest news from Neuromics, customers, collaborators, and friends. Here we will post publications, data, new reagents, and methods.
For additional information on Neuroscience updates check out our Neuroscience Blog.
Our Antibodies Are Crushing Neuroscience Research
When Neuromics opened in 2005, we solely provided neuroscience research antibodies. While we have expanded our selection products beyond neuroscience research antibodies, these antibodies remains at the core of our business. That's why it's still satisfying to see publications from customers using these antibodies (view them all here), like in three neuroscience publications new this month we'd like to highlight.
In the first publication, Iwate Medical University scientists studied the morphology of P2X3 in rat models utilizing our rabbit anti-P2X3 antibody (cat.# RA10109). Specifically, the investigators explored how P2X3-immunoreactive nerve endings and serosal ganglia interact in the rat gastric antrum.
Image: P2X3 (RA10109) Staining in Rat DRG. Working dilution 1:100 - 1:300.
Read more to learn about the other two publications...
Congrats to SSFC on a Great Season
As many of you know, Neuromics is the official title sponsor of Sunflower State FC (SSFC), a semi-pro soccer team based in Kansas City. We'd like to congratulate them on their success during this past season.
In their first season in the UPSL Midwest Conference South Division, they were able to finish in an impressive third place. They started off the season strong, even spending a portion of the season in first place. Down the stretch of the season, they struggled, conceding goals late in games, something we're sure they'll improve upon next season. Two standouts players for SSFC this season were Nick McDonald and Girma Kassa, combining to score 17 of the team's 21 goals this season.
Neuromics couldn't be prouder of the effort the Sunflowers displayed on the field every match. Especially when considering all the impressive things the players are doing off the field (learn more).
Read more to learn how you can support SSFC...
Neuromics HRMECs Prove Their Consistency
Whether it is a publication from a customer or through generated data, Neuromics is always looking to validate our reagents so that researchers can truly trust them. We've just received data (read here) to further demonstrate the trustworthiness of our human retinal microvascular endothelial cells (HRMECs) (cat.no. HEC09).
When culturing cells, consistency is necessary. It is impossible for researchers to rely on reagents that don't perform similarly when using an identical protocol.
To demonstrate the consistency of our HRMECs, we plated HRMECs in an 8-well chamber slide (a-h). The cells were stained with diluted primary antibodies CD31 (mouse anti-human BBA7 from R&D, 12 ug/ml) and von Willebrand factor (vWF) (rabbit anti-human from Abcam ab6994, 1:400). Both CD31 and vWF are used as markers of endothelial cells.
The results, shown in the images to the right (a-d in top image, e-h in bottom image), display that our endothelial cells are consistent in their expression of CD31 (green) and vWF (red). Overlap of expression of CD31 and vWF can be seen in the yellow color (expression of both green and red). While there is some variation in the number of cells co-expressing both CD31 and wWF, it falls within the expected range of statistical error.
Read more to view images of wells e-h...
Our Reagents are Helping Answer Questions About COVID-19
With COVID-19 affecting the globe for well over a year at this point, many researchers have shifted their focus to the virus. While there are many COVID-19 related questions still needing answers, it is incredible what the scientific community has achieved in such a short period of time.
Our reagents have been used by customers in a handful of publications that have helped us learn more about the virus. We've just added a new page to our website to compile all these publications. Visit it here.
Image: Detected auto Ig levels in specific cell types, including our human small intestine endothelial cells.
Included is a publication from researchers at Emory University comparing the plasma of COVID-19 patients to healthy patients to study the pathogenesis of severe COVID-19. In this research, they used our Human Small Intestine Endothelial Cells (cat.# HEC15). Check out this blog post to learn more.
A second publication utilizes our Human Brain Microvascular Endothelial Cells (cat.# HEC02) to find a microRNA capable of targeting Neuropilin-1, a transmembrane glycoprotein that plays a role in the cellular entry of the SARs-CoV-2 virus. Learn more.
New Peptides for COVID-19 Research
As always, Neuromics is looking to expand our offering of products to make sure researchers have the tools they need. Considering the times we're in, SARS-CoV-2 research reagents is an area there is a need we're looking to fill.
Last month, IBA Lifesciences released a number of new peptides for SARS-CoV-2 research. As many of you already know, Neuromics is IBA's United States distributor, giving us and our customers access to these six new peptides.
The six peptides are recombinantly expressed MHC class I molecules that present a peptide from the SARS-CoV-2 virus. The various molecules present different peptides from the virus, allowing for specific research targets.
Using these molecules in combination with the MHC I Streptamer® approach, applications include fluorescent cell staining and sorting, magnetic cell isolation, and affinity chromatographic cell isolation.
Read more to view the products and learn more.