The latest news from Neuromics, customers, collaborators, and friends. Here we will post publications, data, new reagents, and methods. 

For additional information on Neuroscience updates check out our Neuroscience Blog

Our HRMECs Enable Diabetes Research

Our Human Retinal Microvascular Endothelial Cells (HRMECs) (cat. HEC09) have a history of performing for researchers studying diabetic retinopathy. In the past, we've seen the cells used to investigate the viability of a drug as a treatment in one study and the role of a long non-coding RNA in another paper. Now, the cells are back again, proving their consistency and reliability in a publication released this month.

Image: Formation of tube networks in Neuromics HRMECs in normal glucose (NG) and high glucose (HG) conditions.

Investigators at Shandong University in China subjected our HRMECs to high glucose (HG) conditions to create an in vitro diabetic retinopathy model. They wanted to study the role of circular RNAs (circRNAs) in regulating HG-induced apoptosis in the HRMECs. Finding that hsa_circ_0000880 was upregulated in the cells and that apoptosis decreased in the hsa_circ_0000880 knockout model, the researchers suggest it could be a future therapeutic target for diabetic retinopathy. You can read the full study here.

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Save on Preferred FBS This Spring

Are you planning any cell culturing projects this Spring? Now is the time to save big on our Preferred Fetal Bovine Serum (FBS) (cat. FBS007). Neuromics Preferred FBS is the best bang for your buck and is now only $250/500 ml through the end of May.

Like all our FBS products, Preferred FBS is manufactured in a fully integrated environment from raw material collection to finished product. It is triple 0.1 μm filtered and free of viruses and mycoplasma. A heat inactivated version (cat. FBS007-HI) is also available and on sale ($255/500 ml).

Preferred FBS offers a level of quality to grow most cell types while being available at the lowest price. We encourage all of our FBS customers to give it a shot. However, if you are working with more sensitive cell types or need specialty FBS for your application, we always have further options available. Check out an explanation of all our FBS products here.

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New Medias for Neurite Outgrowth & Tube Formation

Along with our consistent efforts to introduce new types of human cells, we are always testing and validating new media formulations so customers can get the most out of our cells. We have now released two new media products - Universal Neurite Outgrowth Media (cat. HNM004) and Universal Tube Formation Media (cat. MED003). These formulations enable researchers to perform new applications and experiments.

Top Image: Primary Human Neurons (cat. HNC001) cultured using Universal Neurite Outgrowth Media. Neurite formation can be seen.

Neurite outgrowths occur when developing neurons produce projections as they grow in response to guidance cues. The formation of neurites is critical for communication between neurons. Universal Neurite Outgrowth Media stimulates neurite formation in vitro to further understand the process. Check out the media here

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Cancer Associated Fibroblasts (CAFs) That Deliver

Last year, we focused on adding new types and versions of Primary Human Cancer Associated Fibroblasts (CAFs). With the cells playing a growing role in understanding the tumor microenvironment, it was a no-brainer to expand our offerings. Ultimately, we now have CAFs from eleven tumor types and four immortalized versions.

Image: Colorectal tumor CAFs and DLD-1 spheroids stained with F-Actin (red), cell nucleus (blue), and E-Cadherin (green).

With the products released and circulating, it is no surprise to see citations starting to highlight them in new research. That was the case for our Colorectal Tumor CAFs (cat. CAF115), which featured in a publication released in January.

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More Research Releases Using Our Bio-Reagents

Last week, we highlighted two new publications using Neuromics fetal bovine serum (FBS). Well, it took no time for our bio-reagents to appear in newly released publications again. Three more publications featuring Neuromics products were published.

In the first study, scientists at the University of Minnesota cultured our human colorectal cancer associated fibroblasts (CAFs) (cat. CAF115) in liver cancer research. The investigators used various cell and mouse models to explore how CAFs are activated to promote metastasis. Read the complete publication here.

The second citation focused on a researcher at Middle East Technical University in Ankara, Turkey, utilizing Neuromics type I rat tendon collagen (4 mg/ml) (cat. TY002) to build a 3D organoid breast cancer model. You can learn more here.

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