Neuromics’ cancer associated fibroblasts are some of our most popular cells. Because of their popularity and performance, they are often used in meaningful published research. In the past month, both our Human Colorectal Tumor CAFs (Cat.# CAF05) and Pancreatic-Stellate Cell CAFs (Cat.# CAF08) have been used in important research.

In a first of its kind study, the mechanical properties of our Colorectal Tumor CAFs was determined. Researchers developed a high-resolution microfabricated sensor which measures cell forces and tissue-stiffness and can apply mechanical stimulation to the tissue, which mimics a cancer tumor environment. Single and multicellular force dynamics of fibroblasts (3T3), human colon (FET) and lung (A549) cancer cells and cancer associated fibroblasts (CAF05) was measured. Tissue stiffness increased by 3 times within 24 hours. Understanding how these cells behave in vivo will help improve the efficacy of new cancer therapies.

Check out the video to the right to see our CAFs in Action!

In the second publication, our Pancreatic-Stellate Cell CAFs were used to evaluate synthesized amalgamated 3D fiber/hydrogel composites. These synthesized fibers exhibited the mechanical performance and biocompatibility to suggest they could be used as tissue engineering scaffolds when their compatibility was tested with our Pancreatic CAFs in vitro.

Check out all of our CAFs on the right.

 

Citations:

  1. Bashar Emon, Zhengwei Li, Md Saddam Hossain Joy, Umnia Doha, Farhad Kosari, and M Taher A Saif. (2020). A Novel Method for Sensor-Based Quantification of Single/Multi-Cellular Traction Dynamics and Remodeling in 3D Matrices.bioRxiv. doi: 10.1101/2020.09.24.311647
  2. Georgia Papaparaskeva, Maria Louca, Chrysovalantis Voutouri, Eugenia Tanasa, Triantafyllos Stylianopoulos, and Theodora Krasia-Christoforou. (2020). Amalgamated Fiber/Hydrogel Composites Based on Semi-Interpenetrating Polymer Networks and Electrospun Nanocomposite Fibrous Mats.European Polymer Journal, 140:110041. doi: 10.1016/j.eurpolymj.2020.110041
NameCatalog #TypeSpeciesApplicationsSizePrice
Glioblastoma CAFsCAF03Cell Growth MediaHumanCell Assays1,000,000 Cells$1,650.00
Human Breast CAFsCAF06Human Primary CAFsHumanCell Assays1,000,000 cells$2,055.00
Human Colorectal Tumor CAFsCAF05Human Primary CAFsHumanCell Assays1,000,000 cells$899.00
Human Endometrial Adenocarcinoma CAFsCAF01Human Primary CAFsHumanCell Assays1,000,000 cells$899.00
Human Lung Adenocarcinoma CAFsCAF07AHuman Primary CAFsHumanCell Assays1,000,000 cells$915.00
Human Lung Squamous Cell Tumor CAFsCAF07SCHuman Primary CAFsHumanCell Assays1,000,000 cells$915.00
Human Melanoma CAFsCAF09Human Primary CAFsHumanCell Assays1,000,000 cells$1,079.00
Human Ovarian Serous Tumor CAFsCAF02Human Primary CAFsHumanCell Assays1,000,000 cells$899.00
Human Pancreatic CAF-Stellate CellsCAF08Human Primary CAFsHumanCell Assays1,000,000 Cells$1,650.00