Channels

Potassium channels are the most diverse group of the ion channel family. They are important in shaping the action potential, and in neuronal excitability and plasticity. In addition, they regulate heart rate, insulin secretion, epithelial electrolyte transport, smooth muscle contraction, and cell volume.

Changes in K+ channel function have been associated with cardiac hypertrophy and failure, apoptosis and oncogenesis, and various neurodegenerative and neuromuscular disorders.

Calcium (Ca2+) Channels are important in shaping the action potential, and in neuronal excitability and plasticity. In addition, they regulate heart rate, insulin secretion, epithelial electrolyte transport, smooth muscle contraction, and cell volume.

Neuromics offers many antibodies that allow one to research the function of these channels.

Ligand-gated ion channels (LGICs), also referred to as ionotropic receptors or channel-linked receptors, are a group of transmembrane ion channels that are opened or closed in response to the binding of a chemical messenger, (i.e., a ligand), such as a neurotransmitter.

Transient Receptor Potential Channels (TRP Channels) are a group of ion channels located mostly on the plasma membrane of numerous animal cell types. There are many different types of TRP Channels (TRPA, TRPV, TRPM, etc.). These channels are an important part of neurons and their function is important to understand for neuroscience.

The acid-sensing ion channel family (ASIC) comprises six discrete ASIC subunits (ASIC 1A, ASIC 1B, ASIC 2A, ASIC 2B, ASIC 3, ASIC 4) that detect tissue acidosis (i.e. a decrease in pH). This acidosis phenomenon is a  response to tissue injury, pain and inflammation.