Product Details
Catalog Number: RA19015
Applications: WB
Type: Rabbit IgG
Dilutions: WB 1:500 -1:1000
Immunogen: ERLLREYPQSFEKGV of the N terminus of SHANK1a
Storage: Maintain at +2-8 degrees C for 3 months or at -20 degrees C for longer periods. Stable for 1 year. Avoid repeated freeze-thaw cycles.
Format A: Affinity Purified
Format B: liquid
Species Reactivity: Human, Mouse, Rat
Downloads: Datasheet (pdf)
Product Sizes
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100 ug$225.00Add to Cart

Shank is a novel family of postsynaptic density proteins (PSD) that bind to PSD-95-associated protein GKAP. Its putative function is to act as a scaffold protein in the PSD to cross-link NMDA receptors/PSD-95 complexes and couple them to regulators of the actin cytoskeleton. Shank1a is a splice variant of Shank1.

Shank1 A has also been found to be associated with L-type Ca2+ channels.  Olson et al., J Neurosci. 2005, 25:1050-62; Zhang et al., J Neurosci. 2005, 25:1037-49) the same channels used by photoreceptors for transmitter release.




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