Our reagents have a long history of enabling neurodegenerative disease research. Some of the highlights include our Human 3D Blood-Brain Barrier (BBB) Model (cat. 3D45002) being used in Alzheimer's research and our Rabbit Polyclonal GFAP antibody (cat. RA22101) being utilized in a Parkinson's disease study. Then, we see there is a just-released study that will be immediately added to the highlight reel.

Researchers from the Mayo Clinic used our Premium US Origin Fetal Bovine Serum (FBS) (cat. FBS001) to culture HEK293E cells and primary human dermal fibroblasts in a new publication. The investigators focused their research on PINK1, a protein involved in mitophagy. They set out to build a method to sensitively detect and quantify PINK1 protein expression, which previously did not exist.

The scientists developed a sandwich ELISA to measure PINK1 levels in various cells. The research will have major implications for further understanding the involvement of PINK1 in neurodegenerative diseases, especially Parkinson’s and Alzheimer’s. You can read the full paper here.

With summer winding down, it's time to plan for fall research projects. You'll need fetal bovine serum (FBS) if you have any cell culturing lined up. Our FBS inventory has never been more extensive. With several grades, specialty types, and heat-inactivated options, we've got what you need to optimize your cell culturing. Check out all our FBS options here.

Furthermore, our FBS continues to demonstrate its reliability through dozens of customer citations in published research. Two new studies have been published in the last month, which we'd like to highlight.

Image: Immortalized mouse microglia cultured using Neuromics FBS.

In the first paper, scientists at The Roskamp Institute published repetitive mild traumatic brain injury (r-mTBI) research using our heat inactivated premium USA origin FBS (cat. FBS001-HI). r-mTBIs can cause chronic neuroinflammation and microglia activation. The researchers cultured immortalized mouse microglia using our FBS to study the causes of the microglia activation after r-mTBIs along with a drug to treat the condition. Read the study here.

In the last week, Neuromics fetal bovine serum (FBS) was cited in a couple of studies released by Mayo Clinic researchers. We continuously talk about our selection of capable and low priced FBS options. These publications further prove our point. With various grades and specialty types available, our FBS is ready to serve your upcoming cell culturing projects. We suggest you check out our explainer that walks through all our serum offerings.

Image: HeLa cell transfected with scrambled siRNA cultured using Neuromics FBS.

In the first publication, Mayo scientists utilized Premium USA Origin FBS (cat. FBS001) to culture HeLa cells in a neurodegenerative disease study. The investigators performed a genome-wide screening of miRNAs on the HeLa cells to look for inhibitors of the PINK1-PRKN pathway. Mutations in these genes have been implicated in neurodegenerative diseases. Check out the full paper here.

At the core of the Neuromics portfolio are reagents with applications in neuroscience research. As a result, we see a large portion of references relating to neurodegenerative diseases, the brain, pain, and other neuroscience fields.

And while our collection of customer publications proves that our products can be used for so much more (see for yourself here), that theme of neuroscience research continued this past week. Two publications were released using our research tools in Parkinson's disease (PD) studies that we'd like to highlight.

Image: GFAP staining (cat. RA22101) of various parts of the PD mouse brain.

In the first study, researchers from Korea used our Rabbit GFAP Polyclonal Antibody (cat. RA22101). They evaluated various antihistamines as potential therapies for patients with PD. After analyzing South Korean patient data and using various animal models, they found that fexofenadine is a potentially effective option to treat PD. Our antibody was used to stain various parts of the mouse brain in a PD model. We encourage you to check out the full publication here.

In the world of life sciences, successful cell culture is pivotal for achieving accurate and reproducible results. That's why finding a reliable and consistent source of Fetal Bovine Serum (FBS) is so important. With many research proven and affordable FBS options, choosing Neuromics FBS will ensure your desired growth of healthy, vibrant cells.

We firmly believe that the best way to demonstrate the quality of FBS is through results. Thanks to our many customers, we continue to wrack up references and citations from researchers.

Earlier this month, investigators from City of Hope used our heat-inactivated premium imported FBS (USDA approved) (cat. FBS002-HI) in cancer drug discovery research. The FBS was used to culture various neuroblastoma and breast cancer cell lines, along with HEK293T cells. Scientists identified a small molecule called AOH1996 that seemingly kills solid tumors while preserving healthy cells and causing no side effects.

We encourage you to read the full publication to learn more. Also, check out some of the news articles surrounding this "cancer-killing" pill and its promise going forward.

Thanks to the growing number of researchers using our fetal bovine serum (FBS) products, our FBS is being cited in publications on an increasingly frequent basis. In the last week alone, our FBS has popped up in three new studies that demonstrated the versatility of our FBS options. You can explore all our FBS references here.

In the first publication, investigators from Hendrix college used our Premium Imported FBS (cat. FBS002) to culture COS-7 cells. The researchers wanted to better understand how the cancer cell line avoids ferroptosis. Check out the full publication here.

Scientists also utilized our Premium Imported FBS (cat. FBS002) in the second publication to culture C6 rat glioma cells. The researchers from the University at Buffalo were comparing various quantitative phase imaging (QPI) techniques. Learn more here.

In the final study, researchers used our Heat Inactivated Premium USA Origin FBS (cat. FBS001-HI) in cervical cancer research. With our FBS, the investigators cultured two cervical cancer cell lines, DoTc2 and C-33-A. They found that by knocking down HOTAIR in the cells, metastasis of the cells was impaired. Read the study here.

Even though 2023 just started, it's already been a busy couple of weeks for our Fetal Bovine Serum (FBS) in a variety of ways. We've already released a new product, been cited in a publication, and brought back into stock a couple of our most popular FBS lines. Before we dive into the specifics, we should mention that you can explore all of our FBS options here along with at the bottom of the blog.

Starting with the new product, we are now offering Female-Only FBS (cat. FBS001-F). This serum is derived exclusively from the blood of female fetuses for those of you with specific applications in this area. We encourage you to check out the product to learn more.

Next up, there was research recently published referencing the use of our FBS for the culture of HEK-293 cells. Both our Premium USA Origin FBS (cat. FBS001) and Preferred FBS (cat. FBS007) were used by the researchers from Fordham University. The investigators explored the mechanisms behind the cellular internalization and the spreading of misfolded tau which has implications in Alzheimer's Disease. We suggest you read the full publication here. Additionally, you can find all citations using our FBS here.

Researchers from the University of Copenhagen utilized human primary cells from Neuromics in newly published research. With the help of our Human Brain Microvascular Pericytes (cat. HMP104) and our Human Brain Astrocytes (cat. HMP202), the investigators were able to build 3D organoids mimicking the blood-brain barrier (BBB). Furthermore, they used our growth media (pericyte and astrocyte, respectively) to culture both cell types as well.

The scientists were looking into how spirochetes within the Borrelia burgdorferi sensu lato (s.l.) complex cross the BBB. The complex is associated with the tick-borne bacterial central nervous system infection lyme neuroborreliosis (LNB). The Borrelia spirochetes resulted in swelling and the loss of structural integrity of the BBB organoids. The results offer a better understanding of how LNB affects the central nervous system. 

Image: BBB-organoids co-incubated with varios B. burgdorferi s.l. isolates. The image show carboxyfluorescein succinimidyl ester (CFSE stained), Borrelia in green, nuclei in blue (DAPI), and actin in red (phalloidin).

We encourage you to check out the full publication here. If you want to see other publications using our human cells, including our astrocytes and pericytes, they can be found here. And of course, explore all of our human cell types as well.

Culturing cells in your fall research? There's no question that you'll need Fetal Bovine Serum (FBS). Neuromics continues to maintain a healthy inventory of FBS, including multiple grades and specialty lines. We encourage you to explore all of our FBS options here to find the serum matching your specific research applications. Of course, all our FBS is well priced and near the lowest in the market (learn more).

Furthermore, there's no better way to prove the reliability of our FBS than pointing to the many publications referencing it's use. In the past couple of weeks alone, our Premium Imported FBS (cat. FBS002) was cited in two new publications. Check out all publications using our FBS here.

In the first publication, researchers from UKMC used the FBS to culture a variety of cancer cell lines. They were looking into a variety of mutations in the tumor suppressor p53 seen in the various cell lines and potential therapeutic targets. Learn more here.  

In the second publication, scientists from Midwestern University investigated the potential therapeutic uses of flavonoids. In the process, our FBS was used to culture mouse embryonic fibroblast. Check out the publication here.

As anyone who frequents our blog knows, Neuromics is always looking to highlight research using our reagents, especially primary cells and fetal bovine serum (FBS). When a new publication is released using these products, we typically catch them. However, every now and then, one slips through the cracks until it is unearthed. One of the two papers we're featuring here fits that mold. Published in 2020, scientists used our Human Brain Microvascular Endothelial Cells (HBMECs) (cat. HEC02) in cerebral cavernous malformation (CCM) research. The second publication is hot off the press, and uses our always reliable FBS.

As mentioned, this first publication utilizes our HBMECs. Three genes in endothelial cells have historically been linked to CCM disease onset, however, there are instances where patients harbor no mutation at these three loci. Thus, the researchers from the University of Messina in Italy decided to compare the gene expression profile of endothelial cells isolated from CCM specimens with the 'normal' endothelial cells provided by Neuromics and culured with our specialized media. Based on the results of the analysis, the investigators concluded that there must be further genetic factors contributing to CCM outside endothelial cells.  Check out the full publication here.

Image: HBMECs stained with CD146

And read more to learn about the FBS publication!

At Neuromics, we strive to deliver Fetal Bovine Serum (FBS) to researchers that is of the highest quality while being the lowest priced. New data provided to us by researchers at the National Cancer Institute demonstrates that we are winning! 

In evaluating samples of premium FBS from the many providers in the market (including 'the big guys') with a variety of cell lines, Neuromics Premium US Origin FBS (Cat. FBS001) proved to be the best of the bunch. Check out the image to the right (and linked here) to see for yourself (Neuromics is vendor 7 in pink)!

Additionally, this same FBS was also featured in a recent pancreatic cancer related publication. The researchers used our FBS to culture cells as they built a spectroscopic system that can better distinguish cancerous pancreatic tissue from normal tissue. Learn more here and check out all FBS related publications here.

Read more to request a sample and check out all our FBS products...

Neuromics offers many lines and varieties of Fetal Bovine Serum (FBS). And this month, we are introducing one more - Preferred FBS (cat. FBS007). Our Preferred FBS is entering the market with a bang, now being offered for $199/500 ml through the end of November. 

Preferred FBS offers an unbeatable combination of quality (check out its CoA here) and price (like we said - $199/500 ml). We are confident in its ability to culture most cell types, so much so that we encourage you to request a sample. 

Like our other FBS products, Preferred FBS is manufactured in a fully integrated environment from raw material collection to finished product. It is produced to the highest standards in order to reduce risk and product variability, and to ensure product safety and performance. Furthermore, as with our other FBS products, we can heat inactivate our Preferred FBS (cat. FBS007-HI), which is also available for a steal of only $209/500 ml.

Read more to learn more...

As summer swiftly approaches, we’re here to make sure you’re set for all your cell culturing needs throughout the rest of the year. We’ve seen plenty of success with all of our Fetal Bovine Serum products in recent months being applied to a wide variety of cell lines - a big thank you to everyone that has provided us data and information on their usage. 

As always, we’d like to remind you that we have a wide selection of FBS products including specialty and treated FBS such as Charcoal-Stripped, Dialyzed, Exosome Free, Lipid Depleted, and Tet-Free FBS. If you’re interested in testing any of our FBS products, fill out our FBS Sample Request Form to get started.  

Read More...

Another month is in the books, and in the process, our FBS was once again featured in another publication! Researchers from Weill Cornell Medicine published protocols for the development of cancer drug discovery models using our Premium Imported Fetal Bovine Serum (Cat.# FBS002). Read more about it in our blog post here. 

While our FBS002 has the spotlight, we do want to remind you that we offer a wide variety of FBS products, including specialty and treated FBS. As always, we provide samples to test our serum products before purchasing. Simply fill out the Sample Request Form.

Read More...

It's always thrilling for us to hear from customers about how they are utilizing our products, especially when they are being used in research. While customers often share their uses with us upon purchasing, reading publications is another way we learn about how our reagents are helping researchers. For example, last week, researchers from Weill Cornell Medicine published protocols for the development of cancer drug discovery models using our Premium Imported Fetal Bovine Serum (Cat.# FBS002).

The ability of cancer models to truly mimic individual cancers is paramount in understanding how therapeutics can be used to treat cancer. While conventional cancer cell lines are useful models, more recently, patient derived tumor xenografts (PDTXs) have demonstrated the ability to better mimic cancer. PDTXs are models where tissue or cells from a patient’s tumor is extracted before being implanted in immunodeficient mice. By doing this, the tumor cells maintain many of the same properties as the patient’s tumor, creating a perfect model for drug discovery and therapeutics.

Image: Explanation of the overall strategy to develop PDTX models.

Read more to learn about how our FBS was used in their studies...

As you know, Neuromics offers an expansive variety of grades and lines of Fetal Bovine Serum (FBS). As a result, it's no surprise that we're frequently asked questions about the differences in our FBS products. We’d like to clarify the differences in our FBS products to make it easier for researchers to choose the right product.

We currently offer 4 different lines of regular FBS - Preferred, Premium, Standard, and Qualified. Our Preferred FBS offers a level of quality to grow most cell types while being available at the lowest price. We encourage all of our FBS customers to give it a shot!

Our Premium, Standard, and Qualified lines are available in both U.S. origin and Imported origin (USDA approved). The lines of FBS are differentiated by the endotoxin levels in each lot.

• Our Premium FBS endotoxin specification is ≤10 EU/mL.
• Our Standard FBS endotoxin specification is ≤30 EU/mL.
• Our Qualified FBS endotoxin specification is ‘As reported'

With fewer endotoxins, our Premium FBS can be used to culture all cell types, including the most sensitive cell lines. Our Standard FBS can still be relied upon to culture most cell lines and applications. Lastly, our Qualified FBS excels when used for general cell culturing applications.

In addition to endotoxin specifications, all of our FBS products are triple 0.1 μm filtered and free of virus and mycoplasma. They are also available heat-inactivated upon request.

Learn more...

Neuromics fetal bovine serum continues to demonstrate it’s reliability and variability when culturing cells. We claim that our Premium USA Origin FBS (cat.# FBS001) can “be used to culture all cell types,” which continues to be proven in published research from our customers.

Last week, researchers from the Central South University in China published Osteoarthritis (OA) research using our premium FBS. Our FBS was used to enrich media to culture human mesenchymal stem cells (hMSCs). This is the first research to show success using our FBS to culture hMSCs.

Image: Immunostaining analysis of levels of Col2A1 and Aggrecan in transfected cells, cultured with our FBS.

Check out all publications using our FBS to explore all the cell types it can be used to culture.

Neuromics offers a wide variety of Fetal Bovine Serum for all different types of research. We are always excited to see when our FBS is being used in today’s cutting edge research. 

Recently our Premium Fetal Bovine Serum (FBS001) was featured in a publication from the Journal of Autophagy. This paper (linked here) looks into how stress at the molecular level can cause neurological changes that can lead to the development of Parkinson's disease and Alzheimer’s.

Using a new ELISA method, researchers found the enzyme label ubiquitin (Ub) phosphorylated at Ser65 (p-S65-Ub) in unstressed human primary cells. These cells were cultured using Neuromics’ FBS (FBS001). This enzyme label is used as a signal (by PINK1 and PRKN) to break down mitochondria that are not working properly (via the autophagy-lysosome pathway). This is important for research into Parkinson’s Disease and Alzheimer’s Disease.

See all of our FBS Products below. 

Neuromics started providing FBS to researchers in early 2017. Our goal was to provide thorough tested and 9-CFR compliant FBS with the lowest pricing anywhere.

In order to ensure our initial claims are trustworthy, we follow up with all our users and ask that they provide feedback. Here's the latest review-Ordered Fetal bovine serum. Best price and quality" - Juwen D, Albert Einstein College of Medicine. Product: Heat-inactivated FBS, cat no. FBS001-HI.

Images: Keratin filaments are associated with microtubules. A) 3D-SIM imaging of keratin and tubulin immunostaining of RPE cells. The enlargements show the alignment of keratin filaments with microtubules. Scale bar, 5 mm. B) Confocal imaging of keratin and tubulin immunostaining. In control cells, keratin filaments extend to the cell periphery, and the filaments retract into the perinuclear region after 3-h treatment with 10 mM nocodazole to depolymerize microtubules. Scale bar, 10 mm.

Neuromics is proud to offer you the high quality Fetal Bovine Serum, the same serum we use internally, without the high cost. Our customers, researchers like you, agree. 

"Ordered Fetal bovine serum. Best price and quality" - Juwen D, Albert Einstein College of Medicine. Product: Heat-inactivated FBS, cat no. FBS001-HI

"Outstanding service. Fetal bovine serum was of highest quality, easy to order and packaging and shipping were best possible." - Rosemary, University of Buffalo Product: Heat-inactivated FBS, cat no. FBS001-HI (see all of Neuromics reviews here). 

Give our serum a try today! Neuromics US-Origin Fetal Bovine Serum is only 349USD/500ml. Heat-inactivated FBS only 364USD/500ml. Need a large quantity? Bulk discounts are available. Contact us for additional information.