Human GFAP is a 49,749 dalton protein (432 amino acids) expressed in astrocytes. GFAP is an intermediate filament protein and acts as an intracellular structural component of the cytoskeleton. During embryonic and fetal life, GFAP is also expressed by radial glial cells of the CNS. Various mutations of the GFAP gene in humans produce Alexander's disease, one of the leukodystrophies.
Antibodies to GFAP are therefore very useful as markers of astrocytic cells and neural stem cells. In addition many types of brain tumor, presumably derived from astrocytic cells, heavily express GFAP.
Image: Injection of rhHsp70 did not result in overt changes in glial cell activation. Lumbar spinal cord tissue was collected from treated and untreated G93A SOD1 or WT mice on P90. Twenty-five micrograms of protein per lane was loaded into each lane and Western blotting was performed to assess relative levels of GFAP and Iba1. When normalized to actin, quantification of the bands confirmed no change in expression (data not shown). doi:10.1523/JNEUROSCI.4057-07.2007
- Product ReviewsIt was great working with Neuromics. Pete was very helpful and very knowledgeable. Thanks for a great product (GFAP antibody) Product Name: Glial Fibrillary Acidic Protein (GFAP), Rabbit (Cat# RA22101) http://bit.ly/MSw6vc Organization: Case Western Reserve UniversityMadhu Ravikumar - Jul 27, 2014 - Rating: 5.0Excellent and quick delivery. Just wish the products could be a bit cheaper! Product Name: GFAP, Rabbit – (Cat# RA22101) http://bit.ly/MSw6vc Organization: Case Western Reserve UniversityKelsey - Jul 25, 2014 - Rating: 4.0I got my order in a good time frame and nothing was on back order. Have had nothing but good consistent results from Neuromics! Product Name: GFAP, Rabbit – (Cat# RA22101) http://bit.ly/MSw6vc Organization: Case Western Reserve UniversityKelsey - Feb 13, 2014 - Rating: 5.0
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- Frances Y. Cheng, Xi Huang, Anuraag Sarangi, Tatiana Ketova, Michael K. Cooper, Ying Litingtung, Chin Chiang. (2012). Widespread Contribution of Gdf7 Lineage to Cerebellar Cell Types and Implications for Hedgehog-Driven Medulloblastoma Formation. PLoS ONE, 7(4): e35541. doi: 10.1371/journal.pone.0035541
- David J. Gifondorwa, Mac B. Robinson, Crystal D. Hayes, Anna R. Taylor, David M. Prevette, Ronald W. Oppenheim, James Caress, and Carolanne E. Milligan. (2007). Exogenous Delivery of Heat Shock Protein 70 Increases Lifespan in a Mouse Model of Amyotrophic Lateral Sclerosis. The Journal of Neuroscience, doi: 10.1523/JNEUROSCI.4057-07.2007
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