Human GFAP is a 49,749 dalton protein (432 amino acids) expressed in astrocytes. GFAP is an intermediate filament protein and acts as an intracellular structural component of the cytoskeleton. During embryonic and fetal life, GFAP is also expressed by radial glial cells of the CNS. Various mutations of the GFAP gene in humans produce Alexander's disease, one of the leukodystrophies.
Antibodies to GFAP are therefore very useful as markers of astrocytic cells and neural stem cells. In addition many types of brain tumor, presumably derived from astrocytic cells, heavily express GFAP.
- Product ReviewsIt was great working with Neuromics. Pete was very helpful and very knowledgeable. Thanks for a great product (GFAP antibody) Product Name: Glial Fibrillary Acidic Protein (GFAP), Rabbit (Cat# RA22101) http://bit.ly/MSw6vc Organization: Case Western Reserve UniversityMadhu Ravikumar - Jul 27, 2014 - Rating: 5.0Excellent and quick delivery. Just wish the products could be a bit cheaper! Product Name: GFAP, Rabbit – (Cat# RA22101) http://bit.ly/MSw6vc Organization: Case Western Reserve UniversityKelsey - Jul 25, 2014 - Rating: 4.0I got my order in a good time frame and nothing was on back order. Have had nothing but good consistent results from Neuromics! Product Name: GFAP, Rabbit – (Cat# RA22101) http://bit.ly/MSw6vc Organization: Case Western Reserve UniversityKelsey - Feb 13, 2014 - Rating: 5.0
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