As anyone who frequents our blog knows, Neuromics is always looking to highlight research using our reagents, especially primary cells and fetal bovine serum (FBS). When a new publication is released using these products, we typically catch them. However, every now and then, one slips through the cracks until it is unearthed. One of the two papers we're featuring here fits that mold. Published in 2020, scientists used our Human Brain Microvascular Endothelial Cells (HBMECs) (cat. HEC02) in cerebral cavernous malformation (CCM) research. The second publication is hot off the press, and uses our always reliable FBS.
As mentioned, this first publication utilizes our HBMECs. Three genes in endothelial cells have historically been linked to CCM disease onset, however, there are instances where patients harbor no mutation at these three loci. Thus, the researchers from the University of Messina in Italy decided to compare the gene expression profile of endothelial cells isolated from CCM specimens with the 'normal' endothelial cells provided by Neuromics and culured with our specialized media. Based on the results of the analysis, the investigators concluded that there must be further genetic factors contributing to CCM outside endothelial cells. Check out the full publication here.
Image: HBMECs stained with CD146
And read more to learn about the FBS publication!
In this second publication, Korean researcher used our Premium US Origin FBS (cat. FBS001) to culture RAW264.7, a macrophage cell line and YAC-1 lymphoma cells. The scientists were looking at two compounds as potential treatments for immune dysregulation. Based on their findings after incubating the RAW264.7 and YAC-1 cells with the compounds, they found the compounds to be promising. Read the publication for yourself here.
As always, we encourage you to check out all publications using our endothelial cells and FBS. Furthermore, we are always interested in customers sharing data after using our products. Feel free to contact Pete at firstname.lastname@example.org with any data!