Neuromics has an impressive selection of products that have been used in meaningful cancer research. Some of our most popular and research proven products for cancer research are our Cancer Related Fibroblasts (CAFs). Just last week, researchers from Nanyang Technological University in Singapore published cancer research using our Human Colorectal Tumor Cancer Associated Fibroblasts (Cat.# CAF05).

CAFs play a major role in the tumor microenvironment, with implications in tumor growth and metastasis. While research has shown that CAFs can increase the aggressiveness of malignant tumors, other research has concluded that CAFs can suppress cancer progression. These researchers wanted to understand more about the phenotypic processes creating various CAF subsets that either encourage or suppress cancer progression.

Image: Fluorescence images of CAFs cultured in CoAl hydrogels counterstained with live (green) / dead (red) dyes (top, scale bar=200 µm) and nucleus (blue) / F-actin (red) (bottom, scale bar=20 µm).

Read more to learn about their findings.

Using our Human Colorectal Tumor CAFs, which were cultured using our VitroPlus III, Low Serum, Complete Media (Cat.# PC00B1), the investigators built a 3D interpenetrating network hydrogel culture platform that allowed them to control mechanical properties of the tumor microenvironment to learn more about CAF phenotype transition and crosstalk with colorectal cancer cells. The researchers began to see conditions that favored patient survival and vice-versa upon altering the mechanical properties. These findings may open up new avenues of cancer treatment in the future.

Explore all of our CAFs below:

NameCatalog #TypeSpeciesApplicationsSizePrice
Glioblastoma CAFsCAF03Cell Growth MediaHumanCell Assays1,000,000 Cells$1,650.00
Human Breast CAFsCAF06Human Primary CAFsHumanCell Assays1,000,000 cells$2,055.00
Human Colorectal Tumor CAFsCAF05Human Primary CAFsHumanCell Assays1,000,000 cells$899.00
Human Endometrial Adenocarcinoma CAFsCAF01Human Primary CAFsHumanCell Assays1,000,000 cells$899.00
Human Lung Adenocarcinoma CAFsCAF07AHuman Primary CAFsHumanCell Assays1,000,000 cells$915.00
Human Lung Squamous Cell Tumor CAFsCAF07SCHuman Primary CAFsHumanCell Assays1,000,000 cells$915.00
Human Melanoma CAFsCAF09Human Primary CAFsHumanCell Assays1,000,000 cells$1,079.00
Human Ovarian Serous Tumor CAFsCAF02Human Primary CAFsHumanCell Assays1,000,000 cells$899.00
Human Pancreatic CAF-Stellate CellsCAF08Human Primary CAFsHumanCell Assays1,000,000 Cells$1,650.00

Citation

  1. Huan Cao, Hong Sheng Cheng, Jun Kit Wang, Nguan Soon Tan, and Chor Yong Tay. (2020). A 3D Physio-Mimetic Interpenetrating Network-Based Platform to Decode the Pro and Anti-Tumorigenic Properties of Cancer-Associated Fibroblasts.Acto Biomaterialia. doi: 10.1016/j.actbio.2021.03.037.