Product Details
Catalog Number: GP14105
Applications: ICC, IHC
Type: Guinea Pig IgG
Immunogen: (C)TASLDPDDFDPEPSDPLGSP
Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Shipping: Frozen (Polar Packs)
Format A: Whole serum
Format B: liquid
Species Reactivity: Rat
Entrez: 9311
UniProt: Q9UHC3
Downloads: Datasheet (pdf)
Product Sizes
SizeList PricePriceCart
150 ul$456.00$209.00Add to Cart
50 ul$190.00$95.00Add to Cart

The acid-sensing ion channel family (ASIC) comprises six discrete ASIC subunits (ASIC 1A, ASIC 1B, ASIC 2A, ASIC 2B, ASIC 3, ASIC 4) that detect tissue acidosis (i.e. a decrease in pH). This acidosis phenomenon is a  response to tissue injury, pain and inflammation

Images

Detection of ASIC3 expression in normal and CF human lung tissues by immunofluorescence microscopy. Normal (top panels A-C) and CF human lung sections (bottom panels D-F) were labeled with a specific antibody against ASIC3 (green channel) and the DNA-selective Hoechst dye (blue channel). J. Biol. Chem., Vol. 281, Issue 48, 36960-36968, December 1, 2006

Detection of ASIC3 expression in normal and CF human lung tissues by immunofluorescence microscopy. Normal (top panels A-C) and CF human lung sections (bottom panels D-F) were labeled with a specific antibody against ASIC3 (green channel) and the DNA-selective Hoechst dye (blue channel). J. Biol. Chem., Vol. 281, Issue 48, 36960-36968, December 1, 2006

ASIC3 expression compared to other nociceptive ion channels. DRG sections double-labeled for ASIC3 (red) and either P2X3 (green, A) or TRPV1 (green, B); double-labeled cells are yellow or orange. Circle charts show the relative distribution of the three receptors among all DRG neurons. ASIC3 and P2X3 expression overlapped in only 4% of neurons, while some 35% of ASIC3-positive neurons also express TRPV1.

ASIC3 expression compared to other nociceptive ion channels. DRG sections double-labeled for ASIC3 (red) and either P2X3 (green, A) or TRPV1 (green, B); double-labeled cells are yellow or orange. Circle charts show the relative distribution of the three receptors among all DRG neurons. ASIC3 and P2X3 expression overlapped in only 4% of neurons, while some 35% of ASIC3-positive neurons also express TRPV1.

ASIC3 (Dilution 1:10) amd P2X3 (Dilution 1:500) satining of rat Dorsal Root Ganglia (DRGs) of cisplatin-treated animals. After dilution in 0.1 M phosphate-buffered saline (PBS) containing 1.5% normal goat serum and 0.3% Triton X-100 (Sigma), DRG sections were incubated with either guinea pig polyclonal antiserum against synthetic rat ASIC3 and rabbit polyclonal antiserum against synthetic rat P2X3 (1:500; Neuromics).

ASIC3 (Dilution 1:10) amd P2X3 (Dilution 1:500) satining of rat Dorsal Root Ganglia (DRGs) of cisplatin-treated animals. After dilution in 0.1 M phosphate-buffered saline (PBS) containing 1.5% normal goat serum and 0.3% Triton X-100 (Sigma), DRG sections were incubated with either guinea pig polyclonal antiserum against synthetic rat ASIC3 and rabbit polyclonal antiserum against synthetic rat P2X3 (1:500; Neuromics).