TREK-1 is a two-pore-domain background potassium channel expressed throughout the central nervous system. It is opened by polyunsaturated fatty acids and lysophospholipids. As well, it is regulated by various neurotransmitters. It has been shown that alterations in the functioning, regulation, or both of the TREK-1 channel may alter mood. TREK-1 is also activated by volatile anesthetics and has been suggested to be an important target in the action of these drugs. Therefore, this particular K+ channel emerges as a potential innovative target for developing new therapeutic agents for anesthesiology and neurology, such as antidepressants.
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Name Catalog # Size ATPase Na+/K+ transporting alpha 1 MO25023 50 ul KChIP1 K+ channel MO50011 100 ul KChIP2b K+ channel MO50012 100 ul Kir2.1 K+ channel MO50013 100 ul Kir2.2 K+ channel MO50014 100 ul Kv1.1 K+ channel MO50015 100 ul Kv1.2 K+ channel MO50016 100 ul Kv1.3 K+ channel MO50017 100 ul Kv1.4 K+ channel MO50018 100 ul Kv2.1 K+ channel MO50019 100 ul Kv3.1 K+ channel (pSer503) RA25020 100 ul Kv3.1b K+ channel MO50020 100 ul Kv4.2 K+ channel MO50021 100 ul Kv7.1/KCNQ1 K+ channel MO50022 100 ul