Product Details
Catalog Number: RA18010
Applications: WB, IHC
Type: Rabbit IgG
Immunogen: synthetic peptide corresponding to residues surrounding Ser9 of human synapsin I.
Storage: Do not aliquot. Store at -20°C. Avoid freeze-thaw cycles.
Shipping: Frozen (Polar Packs)
Format A: Affinity Purified
Format B: liquid
Species Reactivity: Mouse, Rat
Entrez: 6853
UniProt: P17600
Downloads: Datasheet (pdf)
Product Sizes
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100 ul$387.00Add to Cart

The synapsins are a family of proteins that have long been implicated in the regulation of neurotransmitter release at synapses. Specifically, they are thought to be involved in regulating the number of synaptic vesicles available for release via Exocytosis. All synapsins contain a short amino-terminal domain that is highly conserved and phosphorylated by PKA or CaM kinase I. Phosphorylation of synapsin amino-terminal domain at serine 9 inhibits its binding tophospholipids and dissociates synapsins from synaptic vesicles.

Images

Synapsin and CREB staining of of mouse retina. Western blot analysis of mouse brain homogenates, untreated or phosphatase-treated, using Phospho-Synapsin (Ser9) (upper) or Synapsin Antibody (lower).

Synapsin and CREB staining of of mouse retina. Western blot analysis of mouse brain homogenates, untreated or phosphatase-treated, using Phospho-Synapsin (Ser9) (upper) or Synapsin Antibody (lower).