Myristolyated alanine rich C-kinase substrate, hence MARCKS, was originally discovered by as a major substrate for protein kinase C in the brain and other tissues. MARCKS interacts with actin and calcium in a manner regulated by protein kinase C. It is a major protein of the brain concentrated in the synapses of neurons and is membrane localized due to the N-terminal lipid myristoyl group. Antibody to MARCKS can therefore be used as a marker of synaptic regions. Genetic knock out of MARCKS in transgenic mice is perinatal lethal and associated with aberrant brain development suggesting a fundamental importance in the CNS.
This antibody was made against recombinant full length human MARCKS expressed in and purified from E. coli. The antibody works well on human cells and tissues but is not recommended for work on rodent material.
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