Product Details
Catalog Number: MO22164
Applications: ICC, WB, IHC, IF
Type: Mouse IgG
Immunogen: synthetic peptides VESGSLEDDWDFLPPKKI corresponding to amino acids 191-208 of human calreticulin, including the LC3 interacting region or LIR.
Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Shipping: Frozen (Polar Packs)
Format A: Affinity Purified
Format B: liquid
Species Reactivity: Human, Mouse, Rat
Entrez: 811
UniProt: P27797
Downloads: Datasheet (pdf)
Product Sizes
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100 ul$325.00Add to Cart

Calreticulin was first identified as a calcium binding protein, but it also appears to be a multifunctional protein found predominately in the endoplasmic reticulum (ER). Calreticulin appears to buffer ER Ca2+ levels in the ER, which affects intracellular calcium signaling. It also functions as an autophagy receptor and may also act as a molecular chaperone. Calreticulin was found to localize to intracellular, cell surface, and extracellular compartments, from which calreticulin regulates a variety of important biological processes such as cell proliferation, cell adhesion, migration and cell anoikis. Calreticulin on the cell surface may mediate phagocytosis of apoptotic or dying tumor cells by triggering immune responses and allowing the immune system to remove tumor cells.

Images
HeLa cell cultures were stained with MO22164 antibody (red).  Calreticulin predominately localized in vesicles and the ER. Cells were counterstained with our chicken polyclonal antibody to Vimentin (CH22108) in green. Blue is a DNA stain.

HeLa cell cultures were stained with MO22164 antibody (red). Calreticulin predominately localized in vesicles and the ER. Cells were counterstained with our chicken polyclonal antibody to Vimentin (CH22108) in green. Blue is a DNA stain

HeLa cell cultures were stained with MO22164 antibody (red).  Calreticulin predominately localized in vesicles and the ER. Cells were counterstained with our chicken polyclonal antibody to Vimentin (CH22108) in green. Blue is a DNA stain.

HeLa cell cultures were stained with MO22164 antibody (red). Calreticulin predominately localized in vesicles and the ER. Cells were counterstained with our chicken polyclonal antibody to Vimentin (CH22108) in green. Blue is a DNA stain