Transient receptor potential ion channels (TRPCs) are a superfamily of six transmembrane segment-spanning, gated cation channels. TRPA1 is a TRP-related channel that responds to cold temperatures and pungent compounds and plays a role in both nociceptor and hair cell transduction. It is a transformation-associated gene product in lung epithelia, whereas its protein distribution is primarily restricted to sensory neurons. Blocking TRPA1 may be a therapeutic target for treating cold hyperalgesia caused by inflammation and nerve damage. It is now known that TRPA1 protein is also widely expressed outside of the CNS and is dys-regulated during oncogenic transformation.
- Product Reviews
- Product Publications
- Mayur J. Patil, Margaux Salas, Siarhei Bialuhin, Jacob T. Boyd, Nathaniel A. Jeske, Armen N. Akopian. (2019). Sensitization of small‐diameter sensory neurons is controlled by TRPV1 and TRPA1 association. The FASEB Journal. https://doi.org/10.1096/fj.201902026R
- Sarah Krupp. (2016). Effects of neonatal capsaicin on formalin-induced ATF3 expression in the adult rat. University of Louisville, ThinkIR: The University of Louisville's Institutional Repository Electronic Theses and Dissertations. doi: 10.18297/etd/2535
- Yun Sook Kim, PhD, Hoon Kap Jung, DDS, Tae Kyung Kwon, DDS, Chin Soo Kim, DDS, PhD, Jin Hyun Cho, DDS, PhD, Dong Kuk Ahn, DDS, PhD, Yong Chul Bae, DDS, PhD. (2012). Expression of Transient Receptor Potential Ankyrin in Human Dental Pulp. Journal of Endodontics, doi: 10.1016/j.joen.2012.04.024
If you've used this product in a publication, let us know. Email email@example.com, with the publication details and you could be eligible for an Amazon gift card.
- Related Products
Name Catalog # Size Trp-p8 RA19043 100 ul TRPA1 RA25013 100 ul TRPC4 MO50009 100 ug TRPC5 MO50010 100 ul TRPC7 GT41031 100 ug TRPM2 RA25034 100 ul TRPM6 (Chak2) GP14108 100 ul TRPM7 GT41030 100 ug VR1 (TRPV1) GT15129 100 ug VR1 C-terminus (TRPV1) GP14100 150 ul VR1 C-terminus (TRPV1) GP14100 50 ul VR1 C-Terminus (TRPV1) - mouse specific RA14113 100 ul VR1 C-Terminus (TRPV1) - mouse specific RA14113 50 ul VR1 N-Terminus (TRPV1) RA10110 150 ul VR1 N-Terminus (TRPV1) RA10110 50 ul