Basic fibroblast growth factor is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis. Three alternatively spliced variants encoding different isoforms have been described. The heparin-binding growth factors are angiogenic agents in vivo and are potent mitogens for a variety of cell types in vitro. There are differences in the tissue distribution and concentration of these 2 growth factors.
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- Hoda Elkhenany, Alexander Roy Andras Szojka, Aillette Mulet-Sierra, Yan Liang, Melanie Kunze, Xiaoyi Lan, Mark Sommerfeldt, Nadr Jomha, and Adetola Bamidele Adesida. (2020). Bone Marrow Mesenchymal Stem Cells-Derived Tissues are Mechanically Superior to Meniscus Cells. Tissue Engineering Part A. doi: 10.1089/ten.TEA.2020.0183
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