Product Details
Catalog Number: RA18004
Applications: ICC, WB, IHC, IP
Type: Rabbit IgG
Immunogen: Peptide corresponding to residues surrounding amino acid 330 of human presenilin 2
Storage: Do not aliquot. Store at -20°C. Avoid freeze-thaw cycles.
Shipping: Frozen (Polar Packs)
Format A: Affinity Purified
Format B: liquid
Species Reactivity: Human, Mouse, Rat, Primate
Entrez: 5664
UniProt: P49810
Downloads: Datasheet (pdf)
Product Sizes
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100 ul$387.00Add to Cart

Presenilin-1 (PS-1) and Presenilin-2 (PS-2) are integral membrane proteins that contain multiple transmembrane domains. Both are predominantly located within the endoplasmic reticulum (ER) and early Golgi apparatus. They are primarily expressed in neurons and are ubiquitously expressed in the brain. PS-1 and PS-2 are proteolytically cleaved to generate an N-terminal fragment (NTF) and a C-terminal fragment (CTF). Mutations in the gene for Presenilin may play an important role in the pathology of Alzheimer's disease.

Images

Presenilin 2 staining in paraffin-embedded human brain, showing both nuclear and cytoplasmic protein localization. Data courtesy of Cell Signaling Technology, Inc.

Presenilin 2 staining in paraffin-embedded human brain, showing both nuclear and cytoplasmic protein localization. Data courtesy of Cell Signaling Technology, Inc.