Product Details
Catalog Number: RA18020
Applications: WB, IP
Type: Rabbit IgG
Immunogen: Peptide corresponding to residues around valine 293 of human presenilin 1
Format A: Affinity Purified
Format B: liquid
Species Reactivity: Human, Mouse, Rat, Primate
Downloads: Datasheet (pdf)
Product Sizes
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200 ul$332.00Add to Cart

Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2). Presenilins form the catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Evidence suggests cleavage of APP by gamma-secretase and the production of Abeta (42 aa) is likely to play a important or casual role in the development of Alzheimer's disease

Image: Presenilin 1 Antibody detects endogenous levels of the carboxy-terminal fragment of presenilin 1 (~22 kDa). The antibody detects the full length protein (55k Da) to a lesser extent. Western blot image shows extracts from HeLa (1), SK-N-MC (2) and COS (3) cells probed with Presenilin 1 antibody.

Note: Western blot and immunoprecipation protocols on datasheet