Microtubules are associated with a family of proteins called microtubule associated proteins (MAPs), which includes the protein tau and a group of proteins referred to as MAP1, MAP2, MAP3, MAP4, and MAP5. MAP2 is made up of two ~280kDa apparent molecular weight bands referred to as MAP2a and MAP2b. A third lower molecular weight form, usually called MAP2c, corresponds to a pair of protein bands running at ~70kDa on SDS-PAGE gels. All these MAP2 forms are derived from a single gene by alternate transcription, and all share a C-terminal sequence which includes either three or four microtubule-binding peptide sequences, which are very similar to those found in the related microtubule binding protein tau.
This antibody was raised against recombinant human “projection domain”, amino acids 377-1505; which are expressed in MAP2A and MAP2B. MAP2 isoforms are expressed only in neuronal cells and specifically in perikarya and dendrites of neurons; therefore, MAP2 makes an excellent marker for neuronal cells. MAP2A and MAP2B isoforms are expressed later in neuronal development than MAP2C and MAP2D.
- Product Reviews
- Product Publications
If you've used this product in a publication, let us know. Email email@example.com, with the publication details and you could be eligible for an Amazon gift card.
- Related Products
Name Catalog # Size Human LC3A Antibody MO15167 100 ug Human LC3A Antibody MO15168 100 ug MAP2 CH23032 100 ul MAP2 (Microtubule assoc. protein 2) CH22103 50 ul MAP2 (Microtubule assoc. protein 2) MO22116 100 ul MAP2 (Microtubule assoc. protein 2) MO30000 50 ul Tau CH23018 100 ul Tau (Tau 46) MO18002 100 ul Tau /MAPT+ CH22113 100 ul