Product Details
Catalog Number: MO18002
Applications: WB, IHC, IP, IF
Type: Mouse IgG
Immunogen: Native bovine tau and the epitope maps to the carboxy-terminus of the protein.
Storage: Store at 4°C short term. Store at -20°C long term. Avoid freeze-thaw cycles.
Shipping: Frozen (Polar Packs)
Format A: Protein G Purified
Format B: liquid
Species Reactivity: Human, Mouse, Rat
Entrez: 4137
UniProt: P10636
Downloads: Datasheet (pdf)
Product Sizes
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100 ul$332.00Add to Cart

Tau is a heterogeneous microtubule-associated protein that promotes and stabilizes microtubule assembly, especially in axons. Six isoforms with different amino-terminal inserts and different numbers of tandem repeats near the carboxy-terminus have been identified, and tau is hyperphosphorylated at approximately 25 sites by ERK, GSK-3 and CDK5. Phosphorylation decreases the ability of tau to bind to microtubules. Neurofibrillary tangles are a major hallmark of Alzheimer's disease and these tangles are bundles of paired helical filaments composed of hyperphosphorylated tau. In particular, phosphorylation of Ser396 by GSK-3 or CDK5 destabilizes microtubules in Alzheimer's disease. Furthermore, inclusions of tau are found in a number of other neurodegenerative diseases, collectively known as tauopathies.

Images
Tau staining of paraffin-embedded Alzheimer's 'brain'.

Tau staining of paraffin-embedded Alzheimer's brain.

Tau staining of paraffin-embedded Alzheimer's 'brain'.

Tau staining of paraffin-embedded Alzheimer's brain.

Western blot analysis of extracts from mouse and rat brain.

Western blot analysis of extracts from mouse and rat brain.

Western blot analysis of extracts from mouse and rat brain.

Western blot analysis of extracts from mouse and rat brain.