Product Details
Catalog Number: MO22191
Applications: ICC, WB, IHC, IF
Type: Mouse IgG
Dilutions: Immunohistochemistry: 1:1,000 Immunofluorescent: 1:1,000 Immunohistochemistry: 1:1,000 Western Blot: 1:10,000
Immunogen: Recombinant full length 441 amino acid human tau. Epitope located in the peptide HVPGGGNKKIETHKLTFREN, amino acids 362-381
Storage: Store at 4°C short term. Store at -20°C long term. Avoid freeze-thaw cycles.
Shipping: Frozen (Polar Packs)
Format A: liquid
Species Reactivity: Human, Mouse, Rat
Entrez: 4137
UniProt: P10636
Downloads: Datasheet (pdf)
Product Sizes
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100 ul$303.00Add to Cart

Tau is a low molecular weight member of the microtubule associated protein or MAP family. Several serious human diseases are associated with accumulations of tau protein, most notably the neurofibrillary tangles of Alzheimer's disease. Accumulations of tau in neurons are also characteristic of chronic traumatic encephalopathy, Pick’s disease and several other neurodegenerative diseases. Together these disorders are known as “tauopathies”.

Images
Immunofluorescent

Immunofluorescent analysis of cortical neuron-glial culture from E20 rat stained with mouse mAb to MAP-τ, MO22191, dilution 1:2,000 in green, and costained with chicken pAb to GFAP dilution 1:5,000 in red. The blue is DAPI staining of nuclear DNA. MO22191 stains perikarya, dendrites and axons of neurons, while the GFAP antibody labels astrocytes.

Immunofluorescent

Immunofluorescent analysis of cortical neuron-glial culture from E20 rat stained with mouse mAb to MAP-τ, MO22191, dilution 1:2,000 in green, and costained with chicken pAb to GFAP dilution 1:5,000 in red. The blue is DAPI staining of nuclear DNA. MO22191 stains perikarya, dendrites and axons of neurons, while the GFAP antibody labels astrocytes.

Western Blot

Western blot analysis of tissue lysates using mouse mAb to MAP-τ, MO22191, dilution 1:2,000 in green: [1] protein standard (red), [2] rat brain, [3] rat spinal cord, [4] mouse brain, [5] mouse spinal cord. Tau protein is expressed as up to 9 different isoforms of different molecular weight, and so appears as multiple closely spaced bands in the region of the blot from 48 kDa to 67 kDa with some higher molecular weight “big tau” Isoforms.

Western Blot

Western blot analysis of tissue lysates using mouse mAb to MAP-τ, MO22191, dilution 1:2,000 in green: [1] protein standard (red), [2] rat brain, [3] rat spinal cord, [4] mouse brain, [5] mouse spinal cord. Tau protein is expressed as up to 9 different isoforms of different molecular weight, and so appears as multiple closely spaced bands in the region of the blot from 48 kDa to 67 kDa with some higher molecular weight “big tau” Isoforms.