1-EBIO has been shown to be an activator of Ca2+-activated K+ channels (SK) (1). It has also been shown to reverse ischemia-induced cognitive impairment (2) and display neuroprotective effects in ischemia-induced neuronal cell death (3). Research has also shown that 1-EBIO induces embryonic stem cell differentiation into cardiomyocytes (4). The molecule can also encourage production of superoxide and hydrogen peroxide in neutrophils leading to apoptosis (5).
1) Adeagbo et al. (1999), 1-Ethyl-2-benzimidazolinone stimulates endothelial K(Ca) channels and nitric oxide formation in rat mesenteric vessels; Eur. J. Pharmacol., 379 151
2) Orfila et al. (2014), Increasing small conductance Ca2+-activated potassium channel activity reverses ischemia-induced impairment of long-term potentiation; Eur. J. Neurosci., 40 3179
3) Allen et al. (2011), SK2 channels are neuroprotective for ischemia-induced neuronal cell death; J. Cereb. Blood Flow Metab., 31 2302
4) Muller et al. (2012), Ca2+ activated K channels-new tools to induce cardiac commitment from pluripotent stem cells in mice and men; Stem Cell Rev., 8 720
5) Fay et al. (2006), SK channels mediate NADPH oxidase-independent reactive oxygen species production and apoptosis in granulocytes; Proc. Natl. Acad. Sci. USA, 103 17548
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