Product Details
Catalog Number: MC11010
Type: Modulator
Storage: -20°C
Shipping: Ambient
Format B: Powdered
Downloads: Datasheet (pdf)
Product Sizes
SizeList PricePriceCart
25 mg$280.00Add to Cart
5 mg$70.00Add to Cart

EX-527 is a SIRT1 inhibitor (IC50=98 nM). However, it does not inhibit other HDACs or SIRT family members. It also increases p53 acetylation following DNA damage.



1) J.M. Solomon, et al. (2006), Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage; Mol. Cell Biol.; 26 :28


2) J.L. Anderson et al. (2011) Inhibition of SIRT1 Catalytic Activity Increases p53 Acetylation but Does Not Alter Cell Survival following DNA Damage; Mol. Cell, 43:834


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