CD9 Fab-Strep is a recombinantly expressed low affinity Fab fragment fused to a Twin-Strep-tag®. Due to its low affinity for the target, an increase in avidity is required to ensure sufficient binding to the cell surface. Combining Fab-Streps with a Strep-Tactin® backbone leads to the formation of complexes that stably bind to exosomes.
For traceless affinity isolation of exosomes (Fab-TACS® for exosomes), Fab-Streps are combined with Strep-Tactin® TACS Agarose Columns.
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