Product Details
Catalog Number: CH14104
Applications: WB, IHC, IF
Type: Chicken IgY
Immunogen: Recombinant Protein
Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Shipping: Frozen (polar packs)
Format A: liquid
Species Reactivity: Rat
Entrez: 3953
UniProt: P48357
Product Sizes
SizeList PricePriceCart
100 ul$275.00$179.00Add to Cart

Leptin is produced by adipose tissue and interacts with six types of receptor (LepRa–LepRf). LepRb is the only receptor isoform that contains active intracellular signaling domains. This receptor is present in a number of hypothalamic nuclei, where it exerts its effects.

It is also expressed in carotid bodies and plays a role in sleep apnea see: http://ir.lib.uwo.ca/cgi/viewcontent.cgi?article=2487&context=etd

Supporting Products
NameCatalog #Size
LepRb/OBRbP14104100 ug Blocking Protein
Images
Fluorescent photomicrographs showing the effect of IH on OB-RA and ERK 1/2 expression in carotid body glomus cells

Fluorescent (a-c) photomicrographs showing the effect of IH on Ob-Rb (a) and ERK 1/2 (b) expression in carotid body glomus cells. Note that Ob-Rb and ERK 1/2 are co-expressed in the same cells (c). Calibration mark in (a) represents 100 μm and applies to (a-c). Source: http://ir.lib.uwo.ca/cgi/viewcontent.cgi?article=2487&context=etd

Fluorescent photomicrographs showing the effect of IH on OB-RA and ERK 1/2 expression in carotid body glomus cells

Fluorescent (a-c) photomicrographs showing the effect of IH on Ob-Rb (a) and ERK 1/2 (b) expression in carotid body glomus cells. Note that Ob-Rb and ERK 1/2 are co-expressed in the same cells (c). Calibration mark in (a) represents 100 μm and applies to (a-c). Source: http://ir.lib.uwo.ca/cgi/viewcontent.cgi?article=2487&context=etd

OB-Rb staining of 40 µm free-floating rat brainstem

OB-Rb staining of 40 µm free-floating rat brainstem fixed with 4% paraformaldehyde. 1:50 dilution using Rhodamine Red-X, Donkey anti-Chicken for the secondary antibody. Courtesy of Montina Van Meter (Dr’s. Rogers & Hermann - Autonomic Neuroscience Lab, Pennington Biomedical Research Center, Baton Rouge, LA)

OB-Rb staining of 40 µm free-floating rat brainstem

OB-Rb staining of 40 µm free-floating rat brainstem fixed with 4% paraformaldehyde. 1:50 dilution using Rhodamine Red-X, Donkey anti-Chicken for the secondary antibody. Courtesy of Montina Van Meter (Dr’s. Rogers & Hermann - Autonomic Neuroscience Lab, Pennington Biomedical Research Center, Baton Rouge, LA)

LepRb staining in rat intestine.Detection was done using anti-chicken Cy2 conjugated antibodies (green color). Cell nuclei were counterstained with DAPI (blue color). Working dilution is 1:200-1:600.

LepRb staining in rat intestine.Detection was done using anti-chicken Cy2 conjugated antibodies (green color). Cell nuclei were counterstained with DAPI (blue color). Working dilution is 1:200-1:600.

LepRb staining in rat intestine.Detection was done using anti-chicken Cy2 conjugated antibodies (green color). Cell nuclei were counterstained with DAPI (blue color). Working dilution is 1:200-1:600.

LepRb staining in rat intestine.Detection was done using anti-chicken Cy2 conjugated antibodies (green color). Cell nuclei were counterstained with DAPI (blue color). Working dilution is 1:200-1:600.