Glial fibrillary acidic protein (GFAP) is the 10nm or intermediate filament protein found specifically in astrocytic cells in the central nervous system.
GFAP is strongly and specifically expressed in astrocytes and certain other astroglia in the central nervous system, in satellite cells in peripheral ganglia, and in non-myelinating Schwann cells in peripheral nerves. In many damage and disease states GFAP expression is heavily upregulated in astrocytes. In addition neural stem cells frequently strongly express GFAP. Antibodies to GFAP are therefore very useful as markers of astrocytic cells and neural stem cells.
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- Vigo María Belén, Pérez María Julia, De Fino Fernanda, Gómez Gimena, Martínez Sonia A, Bisagno Veronica, Di Carlo María Beatriz, Scazziota Alejandra, Manautou José E, Ghanem Carolina I. (2019). Acute Acetaminophen Intoxication Induces Direct Neurotoxicity in Rats Manifested as Astrogliosis and Decreased Dopaminergic Markers in Brain Areas Associated With Locomotor Regulation. Biochemical Pharmacology. https://doi.org/10.1016/j.bcp.2019.113662
- Victoria Sofía Berenice Wies Mancini Juana María Pasquini Jorge Daniel Correale Laura Andrea Pasquini (2018). Microglial modulation through colony‐stimulating factor‐1 receptor inhibition attenuates demyelination. Glia. https://doi.org/10.1002/glia.23540
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