Glial fibrillary acidic protein (GFAP) is the 10nm or intermediate filament protein found specifically in astrocytic cells in the central nervous system.
GFAP is strongly and specifically expressed in astrocytes and certain other astroglia in the central nervous system, in satellite cells in peripheral ganglia, and in non-myelinating Schwann cells in peripheral nerves. In many damage and disease states GFAP expression is heavily upregulated in astrocytes. In addition neural stem cells frequently strongly express GFAP. Antibodies to GFAP are therefore very useful as markers of astrocytic cells and neural stem cells.
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- Vigo María Belén, Pérez María Julia, De Fino Fernanda, Gómez Gimena, Martínez Sonia A, Bisagno Veronica, Di Carlo María Beatriz, Scazziota Alejandra, Manautou José E, Ghanem Carolina I. (2019). Acute Acetaminophen Intoxication Induces Direct Neurotoxicity in Rats Manifested as Astrogliosis and Decreased Dopaminergic Markers in Brain Areas Associated With Locomotor Regulation. Biochemical Pharmacology. https://doi.org/10.1016/j.bcp.2019.113662
- Victoria Sofía Berenice Wies Mancini Juana María Pasquini Jorge Daniel Correale Laura Andrea Pasquini (2018). Microglial modulation through colony‐stimulating factor‐1 receptor inhibition attenuates demyelination. Glia. https://doi.org/10.1002/glia.23540
- Aran Groves, Yasuyuki Kihara, Deepa Jonnalagadda, Richard Rivera, Grace Kennedy, Mark Mayford and Jerold Chun. (2018). A functionally defined in vivo astrocyte population identified by c-Fos activation in a mouse model of multiple sclerosis modulated by S1P signaling: immediate-early astrocytes (ieAstrocytes). eNeuro 2018; doi: 10.1523/ENEURO.0239-18.2018
- J. I. Nagy, & J. E. Rash. (2017). Cx36, Cx43 and Cx45 in mouse and rat cerebellar cortex: species-specific expression, compensation in Cx36 null mice and co-localization in neurons vs. glia. European Journal of Neuroscience. doi: 10.1111/ejn.13614
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- R Joshi, JC Buchanan, H Tavana. (2017). Self-Regulatory Factors of Embryonic Stem Cells in Co-Culture with Stromal Cells Enhance Neural Differentiation. Integrative Biology. doi: 10.1039/C7IB00038C
- Ramila Joshi, James Carlton Buchanan, Sailaja Paruchuri, Nathan Morris, Hossein Tavana. (2016). Molecular Analysis of Stromal Cells-Induced Neural Differentiation of Mouse Embryonic Stem Cells. PLOS One, doi: 10.1371/journal.pone.0166316
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- Cinzia Ambrosi , Cynthia Ren, Gaelle Spagnol, Gabriel Cavin, Angela Cone, Elena E. Grintsevich, Gina E. Sosinsky, Paul L. Sorgen. (2016). Connexin43 Forms Supramolecular Complexes through Non-Overlapping Binding Sites for Drebrin, Tubulin, and ZO-1. PLOS ONE, doi: 10.1371/journal.pone.0157073
- Xiangchen Li, Yu Guo, Yaxin Yao, Jinlian Hua, Yuehui Ma, Changqing Liu, Weijun Guan. (2016). Reversine Increases the Plasticity of Long-Term Cryopreserved Fibroblasts to Multipotent Progenitor Cells through Activation of Oct. Int J Biol Sci 2016; 12(1):53-62. doi: 10.7150/ijbs.12199
- Paula G. Franco, Juana M. Pasquini, Lucas Silvestroff. (2015). Optimizing Culture Medium Composition to Improve Oligodendrocyte Progenitor Cell Yields In Vitro from Subventricular Zone-Derived Neural Progenitor Cell Neurospheres. PLOS ONE, doi: 10.1371/journal.pone.0121774
- David H. McDougal, Gerlinda E. Hermann, and Richard C. Rogers. (2011). Vagal Afferent Stimulation Activates Astrocytes in the Nucleus of the Solitary Tract Via AMPA Receptors: Evidence of an Atypical Neural–Glial Interaction in the Brainstem. The Journal of Neuroscience, 31(39): 14037-14045; doi: 10.1523/ JNEUROSCI.2855-11.2011
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- Verónica I. Landoni, Marcelo de Campos-Nebel, Pablo Schierloh, Cecilia Calatayud, Gabriela C. Fernandez, M. Victoria Ramos, Bárbara Rearte, Marina S. Palermo, and Martín A. Isturiz. (2010). Shiga Toxin 1-Induced Inflammatory Response in Lipopolysaccharide-Sensitized Astrocytes Is Mediated by Endogenous Tumor Necrosis Factor Alpha. Infection and Immunity, p. 1193-1201, Vol. 78, No. 3. doi: 10.1128/IAI.00932-09
- Min-Tsai Liu, Yung-Hui Kuan, Jingwen Wang, René Hen, and Michael D. Gershon. (2009). 5-HT4 Receptor-Mediated Neuroprotection and Neurogenesis in the Enteric Nervous System of Adult Mice. The Journal of Neuroscience, 29(31):9683-9699; doi: 10.1523/JNEUROSCI.1145-09.2009
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