Glial fibrillary acidic protein (GFAP) is the 10nm or intermediate filament protein found specifically in astrocytic cells in the central nervous system.
GFAP is strongly and specifically expressed in astrocytes and certain other astroglia in the central nervous system, in satellite cells in peripheral ganglia, and in non-myelinating Schwann cells in peripheral nerves. In many damage and disease states GFAP expression is heavily upregulated in astrocytes. In addition neural stem cells frequently strongly express GFAP. Antibodies to GFAP are therefore very useful as markers of astrocytic cells and neural stem cells.
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- Victoria Sofía Berenice Wies Mancini Juana María Pasquini Jorge Daniel Correale Laura Andrea Pasquini (2018). Microglial modulation through colony‐stimulating factor‐1 receptor inhibition attenuates demyelination. Glia. https://doi.org/10.1002/glia.23540
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- Cinzia Ambrosi , Cynthia Ren, Gaelle Spagnol, Gabriel Cavin, Angela Cone, Elena E. Grintsevich, Gina E. Sosinsky, Paul L. Sorgen. (2016). Connexin43 Forms Supramolecular Complexes through Non-Overlapping Binding Sites for Drebrin, Tubulin, and ZO-1. PLOS ONE, doi: 10.1371/journal.pone.0157073
- Xiangchen Li, Yu Guo, Yaxin Yao, Jinlian Hua, Yuehui Ma, Changqing Liu, Weijun Guan. (2016). Reversine Increases the Plasticity of Long-Term Cryopreserved Fibroblasts to Multipotent Progenitor Cells through Activation of Oct. Int J Biol Sci 2016; 12(1):53-62. doi: 10.7150/ijbs.12199
- Paula G. Franco, Juana M. Pasquini, Lucas Silvestroff. (2015). Optimizing Culture Medium Composition to Improve Oligodendrocyte Progenitor Cell Yields In Vitro from Subventricular Zone-Derived Neural Progenitor Cell Neurospheres. PLOS ONE, doi: 10.1371/journal.pone.0121774
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- Verónica I. Landoni, Marcelo de Campos-Nebel, Pablo Schierloh, Cecilia Calatayud, Gabriela C. Fernandez, M. Victoria Ramos, Bárbara Rearte, Marina S. Palermo, and Martín A. Isturiz. (2010). Shiga Toxin 1-Induced Inflammatory Response in Lipopolysaccharide-Sensitized Astrocytes Is Mediated by Endogenous Tumor Necrosis Factor Alpha. Infection and Immunity, p. 1193-1201, Vol. 78, No. 3. doi: 10.1128/IAI.00932-09
- Min-Tsai Liu, Yung-Hui Kuan, Jingwen Wang, René Hen, and Michael D. Gershon. (2009). 5-HT4 Receptor-Mediated Neuroprotection and Neurogenesis in the Enteric Nervous System of Adult Mice. The Journal of Neuroscience, 29(31):9683-9699; doi: 10.1523/JNEUROSCI.1145-09.2009
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