Glial fibrillary acidic protein (GFAP) is the 10nm or intermediate filament protein found specifically in astrocytic cells in the central nervous system.
GFAP is strongly and specifically expressed in astrocytes and certain other astroglia in the central nervous system, in satellite cells in peripheral ganglia, and in non-myelinating Schwann cells in peripheral nerves. In many damage and disease states GFAP expression is heavily upregulated in astrocytes. In addition neural stem cells frequently strongly express GFAP. Antibodies to GFAP are therefore very useful as markers of astrocytic cells and neural stem cells.
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- Stephen J. Bonasera, Nicholas W. DeKorver, Tammy R. Chaudoin, Gang Zhao, Dong Wang, and Jyothi Arikkath. (2021). Complement Protein C3 Loss leads to Locomotor Deficits and Altered Cerebellar Internal Granule Cell In Vitro Synaptic Protein Expression in C57BL/6 Mice. Research Square. doi: 10.21203/rs.3.rs-303802/v1
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- Victoria Sofía Berenice Wies Mancini Juana María Pasquini Jorge Daniel Correale Laura Andrea Pasquini (2018). Microglial modulation through colony‐stimulating factor‐1 receptor inhibition attenuates demyelination. Glia. https://doi.org/10.1002/glia.23540
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- Xiangchen Li, Yu Guo, Yaxin Yao, Jinlian Hua, Yuehui Ma, Changqing Liu, Weijun Guan. (2016). Reversine Increases the Plasticity of Long-Term Cryopreserved Fibroblasts to Multipotent Progenitor Cells through Activation of Oct. Int J Biol Sci 2016; 12(1):53-62. doi: 10.7150/ijbs.12199
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