Neurofilaments can be defined as the intermediate or 10nm filaments found in specifically in neuronal cells. In the electron microscope neurofilaments appears as 10nm diameter fibres of indeterminate length which generally have fine wispy protrusions from their sides. They are found particularly abundantly in axons of large projection neurons. Antibodies to the various neurofilament subunits are very useful cell type markers since the proteins are among the most abundant of the nervous system, are expressed only in neurons, and are biochemically very stable.
Some studies have shown that levels of neurofilament heavy and neurofilament light are elevated in patients with Alzheimer's disease, frontotemporal lobe dementia, and vascular dementia.
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- Meng Zhang, Chen Qin, Yufeng Wang, Xuye Hu, Jingge Ma, Hui Zhuang, Jianmin Xue, Li Wan, Jiang Chang, Weiguo Zou, and Chengtie Wu. (2022). 3D Printing of Tree-Like Scaffolds for Innervated Bone Regeneration. Additive Manufacturing. doi: 10.1016/j.addma.2022.102721
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- Gayle M. Passmore, Joanne M. Reilly, Matthew Thakur, Vanessa N. Keasberry, Stephen J. Marsh, Anthony H. Dickenson and David A. Brown. (2012). Functional significance of M-type potassium channels in nociceptive cutaneous sensory endings. Fronteirs in Molecular Science, doi: 10.3389/fnmol.2012.00063
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- Min-Tsai Liu, Yung-Hui Kuan, Jingwen Wang, René Hen, and Michael D. Gershon. (2009). 5-HT4 Receptor-Mediated Neuroprotection and Neurogenesis in the Enteric Nervous System of Adult Mice. The Journal of Neuroscience, 29(31):9683-9699; doi: 10.1523/JNEUROSCI.1145-09.2009
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