Secretagogin is a member of the EF-hand superfamily of Calcium-binding proteins. It was first cloned from pancreatic islets of Langerhans and neuroendocrine cells and is highly expressed in these tissues (1). Secretagogin is also expressed in numerous brain regions, although the expression pattern is not well conserved from rodents to humans (2,3). While human brain reveals an expression maximum in the cerebellum, in rat and mouse brain by far the highest expression is found in the olfactory bulb. Secretagogin has been shown to be involved in insulin secretion from pancreatic beta cells and is a strong candidate as a biomarker for endocrine tumors (4), and might be a useful biomarker for neuronal damage, stroke, and eventually psychiatric conditions (2,5-7). Moreover, secretagogin has been hypothesized to exert a neuroprotective role in neurodegenerative diseases like Alzheimer’s disease (8).
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